Mitochondrial dysfunction in Crohn's disease

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Comment

Katrina Ray. Nat Rev Gastroenterol Hepatol. 2020 May.

. 2020 May;17(5):260.

doi: 10.1038/s41575-020-0291-y.

No abstract available

Comment on

Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn's disease recurrence.
Khaloian S, Rath E, Hammoudi N, Gleisinger E, Blutke A, Giesbertz P, Berger E, Metwaly A, Waldschmitt N, Allez M, Haller D. Khaloian S, et al. Gut. 2020 Nov;69(11):1939-1951. doi: 10.1136/gutjnl-2019-319514. Epub 2020 Feb 28. Gut. 2020. PMID: 32111634 Free PMC article.
Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis.
Jackson DN, Panopoulos M, Neumann WL, Turner K, Cantarel BL, Thompson-Snipes L, Dassopoulos T, Feagins LA, Souza RF, Mills JC, Blumberg RS, Venuprasad K, Thompson WE, Theiss AL. Jackson DN, et al. Gut. 2020 Nov;69(11):1928-1938. doi: 10.1136/gutjnl-2019-319523. Epub 2020 Feb 28. Gut. 2020. PMID: 32111635 Free PMC article.

1. Jackson, D. N. et al. Mitochondrial dysfunction during loss of prohibitin 1 triggers Paneth cell defects and ileitis. Gut https://doi.org/10.1136/gutjnl-2019-319523 (2020) - DOI - PubMed
1. Khaloian, S. et al. Mitochondrial impairment drives intestinal stem cell transition into dysfunctional Paneth cells predicting Crohn’s disease recurrence. Gut https://doi.org/10.1136/gutjnl-2019-319514 (2020) - DOI - PubMed

1. Rath, E. et al. Mitochondrial function — gatekeeper of intestinal epithelial cell homeostasis. Nat. Rev. Gastroenterol. Hepatol. 15, 497–516 (2018) - DOI