Killing cancer cells by rupturing their lysosomes

Jichuan Qiu¹, Younan Xia^{2

3}

Affiliations

¹ The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
² The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. younan.xia@bme.gatech.edu.
³ School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA. younan.xia@bme.gatech.edu.

PMID: 32203434
DOI: 10.1038/s41565-020-0639-z

Comment

Killing cancer cells by rupturing their lysosomes

Jichuan Qiu et al. Nat Nanotechnol. 2020 Apr.

. 2020 Apr;15(4):252-253.

doi: 10.1038/s41565-020-0639-z.

Authors

Jichuan Qiu¹, Younan Xia^{2

3}

Affiliations

¹ The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
² The Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA. younan.xia@bme.gatech.edu.
³ School of Chemistry and Biochemistry, School of Chemical and Biomolecular Engineering, Georgia Institute of Technology, Atlanta, GA, USA. younan.xia@bme.gatech.edu.

PMID: 32203434
DOI: 10.1038/s41565-020-0639-z

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Comment on

Targeted crystallization of mixed-charge nanoparticles in lysosomes induces selective death of cancer cells.
Borkowska M, Siek M, Kolygina DV, Sobolev YI, Lach S, Kumar S, Cho YK, Kandere-Grzybowska K, Grzybowski BA. Borkowska M, et al. Nat Nanotechnol. 2020 Apr;15(4):331-341. doi: 10.1038/s41565-020-0643-3. Epub 2020 Mar 16. Nat Nanotechnol. 2020. PMID: 32203435

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References

1. Sun, T. et al. Angew. Chem. Int. Ed. 53, 12320–12364 (2014).
1. Shi, J., Kantoff, P. W., Wooster, R. & Farokhzad, O. C. Nat. Rev. Cancer 17, 20–37 (2017). - DOI
1. Lammers, T. et al. Nat. Rev. Mater. 1, 16069 (2016). - DOI
1. Wilhelm, S. et al. Nat. Rev. Mater. 1, 16014 (2016). - DOI
1. Borkowska, M. et al. Nat. Nanotechnol. https://doi.org/10.1038/s41565-020-0643-3 (2020).

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Killing cancer cells by rupturing their lysosomes

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