Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Apr;15(4):247-249.
doi: 10.1038/s41565-020-0674-9.

Insights from nanomedicine into chloroquine efficacy against COVID-19

Tony Y Hu #  1 , Matthew Frieman #  2 , Joy Wolfram  3   4   5   6
Affiliations

Insights from nanomedicine into chloroquine efficacy against COVID-19

Tony Y Hu et al. Nat Nanotechnol. 2020 Apr.

Abstract

Chloroquine — an approved malaria drug — is known in nanomedicine research for the investigation of nanoparticle uptake in cells, and may have potential for the treatment of COVID-19.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Potential mechanism by which chloroquine exerts therapeutic effects against COVID-19.
The proposed mechanism involves chloroquine-induced suppression of PICALM, which prevents endocytosis-mediated uptake of SARS-CoV-2.
See this image and copyright information in PMC

References

    1. Gao, J., Tian, Z. & Yang, X. Biosci. Trends10.5582/bst.2020.01047 (2020).
    1. Wang M, et al. Cell Res. 2020;30:269–271. doi: 10.1038/s41422-020-0282-0. - DOI - PMC - PubMed
    1. Zhu N, et al. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
    1. Haladyj E, Sikora M, Felis-Giemza A, Olesinska M. Reumatologia. 2018;56:164–173. doi: 10.5114/reum.2018.76904. - DOI - PMC - PubMed
    1. Savarino A, Boelaert JR, Cassone A, Majori G, Cauda R. Lancet Infect. Dis. 2003;3:722–727. doi: 10.1016/S1473-3099(03)00806-5. - DOI - PMC - PubMed

Publication types

MeSH terms