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Comment
. 2020 Mar 1;143(3):e19.
doi: 10.1093/brain/awaa029.

Early-onset genetic epilepsies reaching adult clinics

David Lewis-Smith  1   2 , Colin A Ellis  3   4 , Ingo Helbig  3   4   5   6 , Rhys H Thomas  1   2
Affiliations
Comment

Early-onset genetic epilepsies reaching adult clinics

David Lewis-Smith et al. Brain. .
No abstract available

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Figures

Figure 1
Figure 1
Longitudinal analysis of electronic medical record data from 158 individuals recruited within the Epilepsy Neurogenetics Initiative (ENGIN) at Children’s Hospital of Philadelphia with epilepsies attributable to genes from the 104-gene panel in Symonds et al. (2019). (A) The cumulative distribution of seizure onset by age. (B) The cumulative distribution of genetic diagnoses by age, with points indicating the time of individual diagnoses. (C) The number of individuals with genetic epilepsies attending clinic by age in 3-month bins, with and without active prescriptions for 20 common antiepileptic medications. (D) The proportion of individuals with genetic epilepsies who are prescribed antiepileptic medication by time in 3-month bins, with 95% confidence intervals.
See this image and copyright information in PMC

Comment on

  • Incidence and phenotypes of childhood-onset genetic epilepsies: a prospective population-based national cohort.
    Symonds JD, Zuberi SM, Stewart K, McLellan A, O'Regan M, MacLeod S, Jollands A, Joss S, Kirkpatrick M, Brunklaus A, Pilz DT, Shetty J, Dorris L, Abu-Arafeh I, Andrew J, Brink P, Callaghan M, Cruden J, Diver LA, Findlay C, Gardiner S, Grattan R, Lang B, MacDonnell J, McKnight J, Morrison CA, Nairn L, Slean MM, Stephen E, Webb A, Vincent A, Wilson M. Symonds JD, et al. Brain. 2019 Aug 1;142(8):2303-2318. doi: 10.1093/brain/awz195. Brain. 2019. PMID: 31302675 Free PMC article.

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