Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Mar 19;8(3):431.
doi: 10.3390/microorganisms8030431.

The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

Giuseppina Campisciano  1 , Nicolò de Manzini  2   3 , Serena Delbue  4 , Carolina Cason  3 , Davide Cosola  2 , Giuseppe Basile  5 , Pasquale Ferrante  4 , Manola Comar  1   3 , Silvia Palmisano  2   3
Affiliations

The Obesity-Related Gut Bacterial and Viral Dysbiosis Can Impact the Risk of Colon Cancer Development

Giuseppina Campisciano et al. Microorganisms. .

Abstract

An incorrect food regimen from childhood is suggested to negatively impact the gut microbiome composition leading to obesity and perhaps to colon rectal cancer (CRC) in adults. In this study, we show that the obesity and cancer gut microbiota share a characteristic microbial profile with a high colonization by mucin degraders species, such as Hafnia alvei and Akkermansia muciniphila. In addition, the species Clostridium bolteae, a bacterium associated with insulin resistance, dyslipidemia, and inflammation, has been associated with the presence of oncogenic Human Polyomaviruses (HPyVs). Merkel cell Polyomavirus (MCPyV) and BK Polyomavirus (BKPyV) were the most frequently oncogenic viruses recovered in the gut of both obese and tumor patients. Considering the high seroprevalence of HPyVs in childhood, their association with specific bacterial species deserve to be further investigated. Data from the present study highlight the presence of a similar microbiome pattern in CRC and obese subjects, suggesting that obese microbiome may represent an opportunity for tumorigenic/driver bacteria and viruses to trigger cell transformation.

Keywords: cancer pathogenesis; dysbiotic microbiota; gut microbiota; microbiome; obesity.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Bhandari A., Woodhouse M., Gupta S. Colorectal cancer is a leading cause of cancer incidence and mortality among adults younger than 50 years in the USA: A seer-based analysis with comparison to other young-onset cancers. J. Investig. Med. 2017;65:311–315. doi: 10.1136/jim-2016-000229. - DOI - PMC - PubMed
    1. Meza R., Jeon J., Renehan A.G., Luebeck E.G. Colorectal cancer incidence trends in the united states and united kingdom: Evidence of right- to left-sided biological gradients with implications for screening. Cancer Res. 2010;70:5419–5429. doi: 10.1158/0008-5472.CAN-09-4417. - DOI - PMC - PubMed
    1. Mehta R.S., Nishihara R., Cao Y., Song M., Mima K., Qian Z.R., Nowak J.A., Kosumi K., Hamada T., Masugi Y., et al. Association of dietary patterns with risk of colorectal cancer subtypes classified by fusobacterium nucleatum in tumor tissue. JAMA Oncol. 2017;3:921–927. doi: 10.1001/jamaoncol.2016.6374. - DOI - PMC - PubMed
    1. Park Y., Hunter D.J., Spiegelman D., Bergkvist L., Berrino F., Van den Brandt P.A., Buring J.E., Colditz G.A., Freudenheim J.L., Fuchs C.S., et al. Dietary fiber intake and risk of colorectal cancer: A pooled analysis of prospective cohort studies. JAMA. 2005;294:2849–2857. doi: 10.1001/jama.294.22.2849. - DOI - PubMed
    1. Jensen B.W., Bjerregaard L.G., Angquist L., Gogenur I., Renehan A.G., Osler M., Sorensen T.I.A., Baker J.L. Change in weight status from childhood to early adulthood and late adulthood risk of colon cancer in men: A population-based cohort study. Int. J. Obes. 2018;42:1797–1803. doi: 10.1038/s41366-018-0109-y. - DOI - PubMed