Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 19;9(3):248.
doi: 10.3390/antiox9030248.

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Chao-Hsien Chen  1 , Ching-Liang Hsieh  1   2   3
Affiliations
Review

Effect of Acupuncture on Oxidative Stress Induced by Cerebral Ischemia-Reperfusion Injury

Chao-Hsien Chen et al. Antioxidants (Basel). .

Abstract

In this article, we review how acupuncture regulates oxidative stress to prevent ischemia-reperfusion injury. We electronically searched databases, including PubMed, Clinical Key and the Cochrane Library, from their inception to November 2019 by using the following medical subject headings and keywords: acupuncture, ischemia-reperfusion injury, oxidative stress, reactive oxygen species, and antioxidants. We concluded that acupuncture is effective in treating oxidation after ischemia-reperfusion injury. In addition to increasing the activity of antioxidant enzymes and downregulating the generation of reactive oxygen species (ROS), acupuncture also repairs the DNA, lipids, and proteins attacked by ROS and mediates downstream of the ROS pathway to apoptosis.

Keywords: acupuncture; ischemia-reperfusion injury; oxygen free radical.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Flowchart of the search process.
See this image and copyright information in PMC

References

    1. Sies H. Oxidative stress: A concept in redox biology and medicine. Redox. Biol. 2015;4:180–183. doi: 10.1016/j.redox.2015.01.002. - DOI - PMC - PubMed
    1. Manzanero S., Santro T., Arumugam T.V. Neuronal oxidative stress in acute ischemic stroke: Sources and contribution to cell injury. Neurochem. Int. 2013;62:712–718. doi: 10.1016/j.neuint.2012.11.009. - DOI - PubMed
    1. Wu M.Y., Yiang G.T., Liao W.T., Tsai A.P., Cheng Y.L., Cheng P.W., Li C.Y., Li C.J. Current Mechanistic Concepts in Ischemia and Reperfusion Injury. Cell Physiol. Biochem. 2018;46:1650–1667. doi: 10.1159/000489241. - DOI - PubMed
    1. Olmez I., Ozyurt H. Reactive oxygen species and ischemic cerebrovascular disease. Neurochem. Int. 2012;60:208–212. doi: 10.1016/j.neuint.2011.11.009. - DOI - PubMed
    1. Granger D.N., Kvietys P.R. Reperfusion injury and reactive oxygen species: The evolution of a concept. Redox. Biol. 2015;6:524–551. doi: 10.1016/j.redox.2015.08.020. - DOI - PMC - PubMed

LinkOut - more resources