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Review
. 2020 Mar 19;12(3):818.
doi: 10.3390/nu12030818.

Nutrition and the Immune System: A Complicated Tango

Carina Venter  1 , Stefanie Eyerich  2 , Tara Sarin  1 , Kevin C Klatt  3
Affiliations
Review

Nutrition and the Immune System: A Complicated Tango

Carina Venter et al. Nutrients. .

Abstract

Enthusiasm exists for the potential of diet to impact the immune system, prevent disease and its therapeutic potential. Herein, we describe the challenge to nutrition scientists in defining this relationship through case studies of diets and nutrients in the context of allergic and autoimmune diseases. Moderate-quality evidence exists from both human intervention and observational studies to suggest that diet and individual nutrients can influence systemic markers of immune function and inflammation; numerous challenges exist for demonstrating the impact of defined diets and nutrient interventions on clearly influencing immune-mediated-clinical disease endpoints. A growing body of evidence suggests that further consideration of dietary patterns, immune system and gut microbiome composition and function, and subsequent epigenetic modifications are needed to improve our understanding of diet-immune system interactions.

Keywords: fiber; immune system; microbiome; nutrition; omega-3 fatty acids.

PubMed Disclaimer

Conflict of interest statement

C.V. provided educational material or reviewed educational materials for Abbott Laboratories, Danone, and Reckitt Benckiser.

Figures

Figure 1
Figure 1
Omega-6 and Omega-3 fatty acid metabolism.
Figure 2
Figure 2
Future direction of nutritional research.
See this image and copyright information in PMC

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References

    1. Meydani S.N., Das S.K., Pieper C.F., Lewis M.R., Klein S., Dixit V.D., Gupta A.K., Villareal D.T., Bhapkar M., Huang M., et al. Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: A randomized controlled trial in non-obese humans. Aging. 2016;8:1416–1431. doi: 10.18632/aging.100994. - DOI - PMC - PubMed
    1. Allaire J., Couture P., Leclerc M., Charest A., Marin J., Lepine M.C., Talbot D., Tchernof A., Lamarche B. A randomized, crossover, head-to-head comparison of eicosapentaenoic acid and docosahexaenoic acid supplementation to reduce inflammation markers in men and women: The Comparing EPA to DHA (ComparED) Study. Am. J. Clin. Nutr. 2016;104:280–287. doi: 10.3945/ajcn.116.131896. - DOI - PubMed
    1. Huang S.C., Wei J.C., Wu D.J., Huang Y.C. Vitamin B(6) supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis. Eur. J. Clin. Nutr. 2010;64:1007–1013. doi: 10.1038/ejcn.2010.107. - DOI - PubMed
    1. Luukkonen P.K., Sadevirta S., Zhou Y., Kayser B., Ali A., Ahonen L., Lallukka S., Pelloux V., Gaggini M., Jian C., et al. Saturated Fat Is More Metabolically Harmful for the Human Liver Than Unsaturated Fat or Simple Sugars. Diabetes Care. 2018;41:1732–1739. doi: 10.2337/dc18-0071. - DOI - PMC - PubMed
    1. Ulven S.M., Christensen J.J., Nygard O., Svardal A., Leder L., Ottestad I., Lysne V., Laupsa-Borge J., Ueland P.M., Midttun O., et al. Using metabolic profiling and gene expression analyses to explore molecular effects of replacing saturated fat with polyunsaturated fat-a randomized controlled dietary intervention study. Am. J. Clin. Nutr. 2019;109:1239–1250. doi: 10.1093/ajcn/nqy356. - DOI - PMC - PubMed