Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Mar 24;24(1):99.
doi: 10.1186/s13054-020-2779-9.

Heterogeneity of Cardiovascular Response to Standardized Sepsis Resuscitation

Fabio Guarracino  1 , Pietro Bertini  2 , Michael R Pinsky  3
Affiliations
Review

Heterogeneity of Cardiovascular Response to Standardized Sepsis Resuscitation

Fabio Guarracino et al. Crit Care. .

Erratum in

Abstract

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2020. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2020. Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901.

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
A stylized representation of the relation between left ventricular (LV) pressure (Plv) or arterial pressure (Pa) and LV pressure-volume relations during a cardiac cycle and arterial elastance (Ea) (red line) along with the associated formulae defining end-systolic elastance (Ees) (blue line) and Ea. Stroke work (SW) is the area within the LV pressure-volume loop for one cardiac cycle, while the potential energy (PE) is the area sub-served by the Ea and LV end-systolic volume (ESV). LV efficiency (LVef) is the ratio of SW to SW + PE (Reproduced from [5] under a Creative Commons Attribution 4.0 International License)
Fig. 2
Fig. 2
A proposed treatment algorithm to personalize resuscitation in septic patients. Ea arterial elastance
See this image and copyright information in PMC

References

    1. Rhodes A, Evans LE, Alhazzani W, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock: 2016. Intensive Care Med. 2017;43:304–377. doi: 10.1007/s00134-017-4683-6. - DOI - PubMed
    1. Leisman DE, Doerfler ME, Schneider SM, Masick KD, D’Amore JA, D’Angelo JK. Predictors, prevalence, and outcomes of early crystalloid responsiveness among initially hypotensive patients with sepsis and septic shock. Crit Care Med. 2018;46:189–198. doi: 10.1097/CCM.0000000000002834. - DOI - PubMed
    1. Payen D, de Pont AC, Sakr Y, et al. A positive fluid balance is associated with a worse outcome in patients with acute renal failure. Crit Care. 2008;12:R74. doi: 10.1186/cc6916. - DOI - PMC - PubMed
    1. Guarracino F, Ferro B, Morelli A, Bertini P, Baldassarri R, Pinsky MR. Ventriculoarterial decoupling in human septic shock. Crit Care. 2014;18:R80. doi: 10.1186/cc13842. - DOI - PMC - PubMed
    1. Guarracino F, Bertini P, Pinsky MR. Cardiovascular determinants of resuscitation from sepsis and septic shock. Crit Care. 2019;23:118. doi: 10.1186/s13054-019-2414-9. - DOI - PMC - PubMed

Substances