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. 2020 Jun;53(3):368-370.
doi: 10.1016/j.jmii.2020.03.005. Epub 2020 Mar 11.

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Dandan Wu  1 , Xuexian O Yang  2
Affiliations

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

Dandan Wu et al. J Microbiol Immunol Infect. 2020 Jun.

Abstract

COVID-19 emerges as a pandemic disease with high mortality. Development of effective prevention and treatment is an urgent need. We reviewed TH17 responses in patients with SARS-CoV-2 and proposed an FDA approved JAK2 inhibitor Fedratinib for reducing mortality of patients with TH17 type immune profiles.

Keywords: COVID-19; Cytokine storm; JAK2 inhibitor; SARS-CoV-2; TH17.

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Conflict of interest statement

Declaration of Competing Interest All authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Quantitative RT-PCR of cytokine mRNAs in murine TH17 cells. In vitro differentiated TH17 cells were activated with plate-bound anti-CD3 and anti-CD28 and treated with or without IL-23 in the presence of 2 μM Fedratinib (Fedr) or a vehicle (saline) for 4 h. The results were normalized to an internal control Actb and the vehicle treatment was set as 1. Data (mean and s.d.) represent 2 experiments (N = 3 in each group). Two side student T test, ∗, p ≤ 0.05; ∗∗, p ≤ 0.005.
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