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Review
. 2020 May 21;64(6):e00483-20.
doi: 10.1128/AAC.00483-20. Print 2020 May 21.

Updated Approaches against SARS-CoV-2

Haiou Li  1   2 , Yunjiao Zhou  1   2 , Meng Zhang  1   2 , Haizhou Wang  1   2 , Qiu Zhao  1   2 , Jing Liu  3   2
Affiliations
Review

Updated Approaches against SARS-CoV-2

Haiou Li et al. Antimicrob Agents Chemother. .

Abstract

Novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lies behind the ongoing outbreak of coronavirus disease 2019 (COVID-19). There is a growing understanding of SARS-CoV-2 in virology, epidemiology, and clinical management strategies. However, no anti-SARS-CoV-2 drug or vaccine has been officially approved due to the absence of adequate evidence. Scientists are racing to develop a treatment for COVID-19. Recent studies have revealed many attractive therapeutic options, even if some of them remain to be further confirmed in rigorous preclinical models and clinical trials. In this minireview, we aim to summarize the updated potential approaches against SARS-CoV-2. We emphasize that further efforts are warranted to develop the safest and most effective approach.

Keywords: COVID-19; SARS-CoV-2; antiviral drugs; treatment; vaccines.

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Figures

FIG 1
FIG 1
Updated potential approaches against SARS-CoV-2. (A) Dampening of SARS-CoV-2 fusion/entry; disruption of SARS-CoV-2 replication; inhibition of excessive inflammatory response. (B) Convalescent plasma treatment. (C) Vaccines. (D) Combinations of traditional Chinese and Western medicine. ACE2, angiotensin-converting enzyme 2; rhACE2, recombinant human ACE2; HR2P, heptad repeat 2-derived peptides; EK1, a modified OC43-HR2P peptide; 3CLpro, 3C-like protease; RdRps, RNA-dependent RNA polymerases; AAV, adeno-associated virus; IL-6, interleukin-6; TCM, traditional Chinese medicine.
See this image and copyright information in PMC

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