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. 2020 Spring;60(2):77-89.
doi: 10.1097/IIO.0000000000000308.

Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma

Jonathan E Lu, Jessica R Chang, Jesse L Berry, Gino K In, Sandy Zhang-Nunes

Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma

Jonathan E Lu et al. Int Ophthalmol Clin. 2020 Spring.
No abstract available

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Conflict of interest statement

The authors declare that they have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Representative photos of conjunctival melanoma. A, Caruncle involving conjunctival melanoma. A 63-year-old Thai female presented with a rapidly growing pigmented lesion involving the caruncle in the setting of diffuse primary acquired melanosis that had been present for years per the patient. The patient was not primarily surgically resectable but wanted to avoid exenteration and therefore was treated with wide local excision followed by adjunctive cryotherapy to any nodular areas and topical mitomycin C 0.04%. Sentinel lymph node biopsy was deferred and there was no metastatic disease. Her local disease was controlled for 3 years until she was noted to have a local amelanotic recurrence. Head and neck magnetic resonance imaging showed lymph node involvement, which was confirmed on biopsy. She was treated systemically, however succumbed to her disease 4 years after presentation. B, A 65-year-old Hispanic male with rapidly growing pigmented lesion in the setting of primary acquired melanosis. He underwent wide local excision. Pathology was consistent with a conjunctival melanoma. There was no radiologic evidence of locally advanced or metastatic disease.
Figure 2.
Figure 2.
Representative photos of eyelid involving cutaneous melanoma. A, Left upper eyelid melanoma. B, Left lower eyelid/cheek melanoma.
See this image and copyright information in PMC

References

    1. Shields CL, Chien JL, Surakiatchanukul T, et al. Conjunctival tumors: review of clinical features, risks, biomarkers, and outcomes—The 2017 J. Donald M. Gass Lecture. Asia Pac J Ophthalmol (Phila). 2017;6:109–120. - PubMed
    1. De Potter P, Shields CL, Shields JA, et al. Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases. Br J Ophthalmol. 1993;77:624–630. - PMC - PubMed
    1. Seregard S, Kock E. Conjunctival malignant melanoma in Sweden 1969-1991. Acta Ophthalmol (Copenh). 2009;70:289–296. - PubMed
    1. Esmaeli B Patterns of regional and distant metastasis in patients with conjunctival melanoma Experience at a cancer center over four decades. Ophthalmology. 2001;108:2101–2105. - PubMed
    1. Vaziri M, Buffam FV, Martinka M, et al. Clinicopathologic features and behavior of cutaneous eyelid melanoma 1 1. Ophthalmology. 2002;109:901–908. - PubMed

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