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Editorial
. 2020 May;27(5):1451-1454.
doi: 10.1038/s41418-020-0530-3. Epub 2020 Mar 23.

COVID-19 infection: the perspectives on immune responses

Yufang Shi  1   2 , Ying Wang  3 , Changshun Shao  4 , Jianan Huang  4 , Jianhe Gan  4 , Xiaoping Huang  4 , Enrico Bucci  5   6 , Mauro Piacentini  7 , Giuseppe Ippolito  7 , Gerry Melino  8   9
Affiliations
Editorial

COVID-19 infection: the perspectives on immune responses

Yufang Shi et al. Cell Death Differ. 2020 May.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that they have no relevant conflict of interest.

Figures

Fig. 1
Fig. 1. Schematic representation of the progression of COVID-19 infection and potential adjuvant interventions.
After an incubation period, the invading COVID-19 virus causes non-severe symptoms and elicits protective immune responses. The successful elimination of the infection relies on the health status and the HLA haplotype of the infected individual. In this period, strategies to boost immune response can be applied. If the general health status and the HLA haplotype of the infected individual do not eliminate the virus, the patient then enters the severe stage, when strong damaging inflammatory response occurs, especially in the lungs. At this stage, inhibition of hyaluronan synthase and elimination of hyaluronan can be prescribed. Cytokine activated mesenchymal stem cells can be used to block inflammation and promote tissue reparation. Vitamin B3 can be given to patients starting to have lung CT image abnormalities.
See this image and copyright information in PMC

References

    1. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. The New England journal of medicine. 2020. 10.1056/NEJMoa2002032. - PMC - PubMed
    1. Wang D, Hu B, Hu C, Zhu F, Liu X, Zhang J, et al. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. Jama. 2020. 10.1001/jama.2020.1585. - PMC - PubMed
    1. Rothe C, et al. Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany. The New England journal of medicine. 2020;382:970–1. doi: 10.1056/NEJMc2001468.. - DOI - PMC - PubMed
    1. Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. The Lancet Respiratory medicine. 2020. 10.1016/S2213-2600(20)30076-X. - PMC - PubMed
    1. Wang Y, Chen X, Cao W, Shi Y. Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications. Nat Immunol. 2014;15:1009–16. doi: 10.1038/ni.3002.. - DOI - PubMed

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