Probiotics against alleviation of lead toxicity: recent advances
- PMID: 32206029
- PMCID: PMC7071839
- DOI: 10.2478/intox-2019-0010
Probiotics against alleviation of lead toxicity: recent advances
Abstract
Lead is a toxic heavy metal and there is no specific, safe and efficacious therapeutic management of lead toxicity. Scientific literature reported that some probiotic microorganisms alleviated experimentally induced lead toxicity. The present review attempts to collate the experimental studies on probiotics with ameliorative effects. Literature survey revealed that four (4) types of probiotic microorganisms exhibited significant protection from lead toxicity in experimental pre-clinical studies. No clinical study with significant outcome was found in the literature. From the outcomes of the preclinical studies it appears that probiotics are prospective for alleviation and treatment of lead toxicity.
Keywords: lactobacilli; lead; oxidative stress; probiotics.
Copyright © 2019 SETOX & Institute of Experimental Pharmacology and Toxicology, SASc.
Conflict of interest statement
The author reports no conflict of interest. The author alone is responsible for the content and writing of this paper.
References
-
- Aposhian HV, Maiorino RM, Gonzalez-Ramirez D, Zuniga-Charles M, Xu Z, Hurlbut KM, Junco-Munoz P, Dart RC, Aposhian MM. Mobilization of heavy metals by newer, therapeutically useful chelating agents. Toxicol. 1995;97:23–38. - PubMed
-
- Astolfi ML, Protano C, Schiavi E, Marconi E, Capobianco D, Massimi L, Ristorini M, Baldassarre ME, Laforgia N, Vitali M, Canepari S, Mastromarino P. A prophylactic multi-strain probiotic treatment to reduce the absorption of toxic elements: In-vitro study and biomonitoring of breast milk and infant stools. Environ Int. 2019;130:104818. - PubMed
-
- Bhattacharya S. The role of medicinal plants and natural products in melioration of cadmium toxicity. Orient Pharm Exp Med. 2018a;18:177–186.
LinkOut - more resources
Full Text Sources