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. 2020 Mar;23(2):154-162.
doi: 10.5223/pghn.2020.23.2.154. Epub 2020 Mar 4.

Cow's Milk-Related Symptom Score in Presumed Healthy Polish Infants Aged 0-6 Months

Affiliations

Cow's Milk-Related Symptom Score in Presumed Healthy Polish Infants Aged 0-6 Months

Karolina Bigorajska et al. Pediatr Gastroenterol Hepatol Nutr. 2020 Mar.

Abstract

Purpose: The Cow's Milk-related Symptom Score (CoMiSS™), which considers crying, regurgitation, stools, skin and respiratory symptoms, was developed as an awareness tool for evaluating cow's milk-related symptoms. The scoring ranges from 0 to 33. A score ≥12 was proposed as being likely cow's milk-related and suggestive of allergy to cow's milk. This study aimed to determine the age-related CoMiSS™ values in presumed healthy infants in Poland.

Methods: This was a cross-sectional study conducted in well-child clinics in two locations. Parents of the presumed healthy infants aged ≤6 months were approached during a routine checkup/vaccination visit. The exclusion criteria were as follows: presence of acute or chronic diseases, preterm delivery, treatment with therapeutic formula, and use of any food supplements (except vitamins) or medications.

Results: Data from 226 infants were obtained (median age [Q1-Q3], 4 months [3-4]). The overall median (Q1-Q3) and mean (standard deviation) CoMiSS™ values were 4 (2-7) and 4.7 (3.5), respectively. The 95th percentile was 11. Scores on some, albeit not all, components of the CoMiSS™ significantly differed between age groups (crying, stools) or feeding type groups (stools and skin symptoms). Eleven children (4.9%) scored ≥12.

Conclusion: This study adds to earlier age-related CoMiSS™ data by providing CoMiSS™ values in presumed healthy infants in Poland.

Keywords: Food allergy; Food hypersensitivity; Infant; Milk.

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Conflict of interest statement

Conflicts of Interest: The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1. Distribution of Cow's Milk-related Symptom Score (CoMiSS™) total scores.
Fig. 2
Fig. 2. Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by sex.
Fig. 3
Fig. 3. Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by age.
Fig. 4
Fig. 4. Distribution of Cow's Milk-related Symptom Score (CoMiSS™) individual scores by the type of feeding.

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