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. 2020 Mar 17:7:2374289520909497.
doi: 10.1177/2374289520909497. eCollection 2020 Jan-Dec.

Educational Case: Yolk Sac (Endodermal Sinus) Tumor of the Ovary

Pouya Jamshidi  1 , Jerome B Taxy  1
Affiliations

Educational Case: Yolk Sac (Endodermal Sinus) Tumor of the Ovary

Pouya Jamshidi et al. Acad Pathol. .

Abstract

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals.sagepub.com/doi/10.1177/2374289517715040.1.

Keywords: Schiller-Duval body; endodermal sinus tumor; female reproductive; organ system pathology; ovarian neoplasia; pathology competencies; yolk sac tumor.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Cross section of the tumor showing bulging lobulated surfaces with centrally prominent hemorrhagic necrosis.
Figure 2.
Figure 2.
A glomeruloid proliferation of tumor cells around a central core of thin-walled vessels, that is, Schiller-Duval bodies (arrow heads), characteristic of yolk sac tumor. Hematoxylin and eosin (H&E) ×100. Inset. Variably sized eosinophilic hyaline globules accompany the Schiller-Duval bodies (arrows). H&E ×400.
Figure 3.
Figure 3.
Hyaline globules showing positive α-fetoprotein immunoreactivity (arrows), ×200.
See this image and copyright information in PMC

References

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