Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May 15;15(10):1536-1539.
doi: 10.1002/asia.202000298. Epub 2020 Apr 7.

Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents

Xiu-Jie Zhou  1 , Hao-Yang Liu  1 , Zu-Yu Mo  2 , Xian-Li Ma  1 , Yan-Yan Chen  1 , Hai-Tao Tang  2 , Ying-Ming Pan  2 , Yan-Li Xu  1
Affiliations

Visible-Light-Promoted Selenylative Spirocyclization of Indolyl-ynones toward the Formation of 3-Selenospiroindolenine Anticancer Agents

Xiu-Jie Zhou et al. Chem Asian J. .

Abstract

A metal-free and efficient visible-light-induced spirocyclization of indolyl-ynones with diselenides at room temperature under air atmosphere to prepare 3-selenospiroindolenines in moderate to good yields has been developed. The resulting products were tested for in vitro anticancer activity by MTT assay, and compounds 3 c and 3 e showed potent cancer cell-growth inhibition activities.

Keywords: 3-selenospiroindolenines; anticancer agents; photocatalyst-free; spirocyclization; visible-light initiation.

PubMed Disclaimer

References

    1. None
    1. G. Mugesh, W. W. du Mont, H. Sies, Chem. Rev. 2001, 101, 2125-2180;
    1. L. Sancineto, A. Mariotti, L. Bagnoli, F. Marini, J. Desantis, N. Iraci, C. Santi, C. Pannecouque, O. Tabarrini, J. Med. Chem. 2015, 58, 9601-9614;
    1. C. W. Nogueira, G. Zeni, J. B. T. Rocha, Chem. Rev. 2004, 104, 6255-6285;
    1. I. D. Leo, F. Messina, V. Nascimento, F. G. Nacca, D. Pietrella, E. J. Lenardao, G. Perin, L. Sancineto, Mini-Rev. Org. Chem. 2019, 16, 589-601.

MeSH terms

LinkOut - more resources