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Review
. 2020 Mar;35(1):1-6.
doi: 10.3803/EnM.2020.35.1.1.

Impact of Skeletal Muscle Mass on Metabolic Health

Gyuri Kim  1 , Jae Hyeon Kim  2
Affiliations
Review

Impact of Skeletal Muscle Mass on Metabolic Health

Gyuri Kim et al. Endocrinol Metab (Seoul). 2020 Mar.

Abstract

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver, adipose tissue, pancreas, bone, and the cardiovascular system. As individuals age, reduced levels of physical activity and sarcopenia (loss of skeletal muscle mass and strength) are associated with physical frailty and disability. Recently, several studies have suggested that the loss of skeletal muscle mass may contribute to metabolic disease. Therefore, herein, we focus on the relationships between skeletal muscle mass and metabolic diseases, including metabolic syndrome and non-alcoholic fatty liver disease.

Keywords: Metabolic syndrome; Muscle, skeletal; Non-alcoholic fatty liver disease; Sarcopenia.

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Conflict of interest statement

No potential conflict of interest relevant to this article was reported.

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