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. 2020 Mar 23;52(6):675-676.
doi: 10.1016/j.devcel.2020.03.001.

Cohesin Is Out for Stalled Replication Fork Restart

Sebnem Ece Eksi  1 , Joshua C Saldivar  2
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Cohesin Is Out for Stalled Replication Fork Restart

Sebnem Ece Eksi et al. Dev Cell. .
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Abstract

Replication stress underlies many genomic alterations in cancer cells. In this issue of Developmental Cell, Benedict et al. show that WAPL-dependent cohesin removal is needed to restart DNA synthesis at stalled forks and promote survival following replication stress, uncovering an unexpected link between stress and sister chromatid cohesion loss.

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