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. 2020 Mar;25(11):2000266.
doi: 10.2807/1560-7917.ES.2020.25.11.2000266.

Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

Anu Haveri  1 , Teemu Smura  2 , Suvi Kuivanen  2 , Pamela Österlund  1 , Jussi Hepojoki  2   3 , Niina Ikonen  1 , Marjaana Pitkäpaasi  1 , Soile Blomqvist  1 , Esa Rönkkö  1 , Anu Kantele  4 , Tomas Strandin  2 , Hannimari Kallio-Kokko  5 , Laura Mannonen  5 , Maija Lappalainen  5 , Markku Broas  6 , Miao Jiang  1   7 , Lotta Siira  1 , Mika Salminen  1 , Taneli Puumalainen  1 , Jussi Sane  1 , Merit Melin  1 , Olli Vapalahti  2   5 , Carita Savolainen-Kopra  1
Affiliations

Serological and molecular findings during SARS-CoV-2 infection: the first case study in Finland, January to February 2020

Anu Haveri et al. Euro Surveill. 2020 Mar.

Abstract

The first case of coronavirus disease (COVID-19) in Finland was confirmed on 29 January 2020. No secondary cases were detected. We describe the clinical picture and laboratory findings 3-23 days since the first symptoms. The SARS-CoV-2/Finland/1/2020 virus strain was isolated, the genome showing a single nucleotide substitution to the reference strain from Wuhan. Neutralising antibody response appeared within 9 days along with specific IgM and IgG response, targeting particularly nucleocapsid and spike proteins.

Keywords: COVID-19; SARS-CoV-2; antibodies; coronavirus; humoral immunity; immunofluorescence assay; microneutralisation test; western blotting; whole-genome sequencing.

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Conflict of interest statement

Conflict of interest: LS is a co-investigator in an unrelated study, for which THL has received research funding from GlaxoSmithKline Vaccines. The other authors report no potential conflicts of interest.

Figures

Figure 1
Figure 1
Timeline of events around the first COVID-19 case imported to Finland, January–February 2020
Figure 2
Figure 2
Immunofluorescence assay of serum samples, COVID-19 index case, Finland, January–February 2020
Figure 3
Figure 3
Western blot of mock- and SARS-CoV-2 infected Vero E6 cells using patient serum collected 20 days after onset of symptoms, Finland, January–February 2020
See this image and copyright information in PMC

References

    1. World Health Organization (WHO). Novel Coronavirus (2019-nCoV) Situation report - 1. Geneva: WHO, 21 Jan 2020. Available from: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2...
    1. Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW, et al. Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR. Euro Surveill. 2020;25(3). 10.2807/1560-7917.ES.2020.25.3.2000045 - DOI - PMC - PubMed
    1. Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579(7798):265-9. 10.1038/s41586-020-2008-3 - DOI - PMC - PubMed
    1. Korzyukov Y, Hetzel U, Kipar A, Vapalahti O, Hepojoki J. Generation of anti-boa immunoglobulin antibodies for serodiagnostic applications, and their use to detect anti-reptarenavirus antibodies in boa constrictor. PLoS One. 2016;11(6):e0158417. 10.1371/journal.pone.0158417 - DOI - PMC - PubMed
    1. Mäkelä MJ, Puhakka T, Ruuskanen O, Leinonen M, Saikku P, Kimpimäki M, et al. Viruses and bacteria in the etiology of the common cold. J Clin Microbiol. 1998;36(2):539-42. 10.1128/JCM.36.2.539-542.1998 - DOI - PMC - PubMed

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