Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;44(2):1023-1029.
doi: 10.1007/s10143-020-01281-8. Epub 2020 Mar 24.

Elevated body mass index facilitates early postoperative complications after surgery for intracranial meningioma

Matthias Schneider  1 , Valeri Borger  2 , Daniel Grigutsch  3 , Ági Güresir  2 , Anna-Laura Potthoff  2 , Markus Velten  3 , Hartmut Vatter  2 , Erdem Güresir  2 , Patrick Schuss  2
Affiliations

Elevated body mass index facilitates early postoperative complications after surgery for intracranial meningioma

Matthias Schneider et al. Neurosurg Rev. 2021 Apr.

Abstract

Surgical resection represents the primary treatment option for patients suffering from intracranial meningioma. However, early postoperative complications significantly worsen initial favorable postoperative outcomes. Therefore, the ability to preoperatively assess potential risk factors for early postoperative unfavorable events is important to preselect critical patients who might require special attention during clinical management. In the current study, we therefore analyzed our institutional database in order to identify risk factors associated with early postoperative complications after initial meningioma resection. Between 2014 and 2017, 202 patients with intracranial supratentorial meningioma were surgically treated at the authors' institution. Early postoperative complications were defined as any postoperative event requiring further surgical measures within 30 days following initial meningioma resection. A multivariate analysis was performed to identify independent risk factors associated with postoperative complications after surgical meningioma therapy. Overall, 13 out of 202 meningioma patients developed early postoperative complications (6%). The multivariate analysis revealed obesity in terms of elevated body mass index (BMI ≥ 30 kg/m2) (p = 0.03), the presence of atrial fibrillation (p = 0.001) as well as the preoperative Karnofsky Performance Status Scale < 70% (p = 0.004) as independent predictors for early postoperative complications in the course of supratentorial meningioma resection. Obesity is associated with a higher risk of postoperative unfavorable events that require further surgical treatment. Furthermore, the present study identifies several additional risk factors for the development of early postoperative complications after intracranial meningioma resection enabling to preoperatively select for high-risk patients that might require special attention in clinical and surgical management.

Keywords: Body mass index; Cranial surgery; Meningioma; Postoperative complications.

PubMed Disclaimer

References

    1. Ostrom QT, Gittleman H, Fulop J, Liu M, Blanda R, Kromer C, Wolinsky Y, Kruchko C, Barnholtz-Sloan JS (2015) CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2008-2012. Neuro Oncol 17(Suppl 4):iv1–iv62. https://doi.org/10.1093/neuonc/nov189 - DOI - PubMed - PMC
    1. Whittle IR, Smith C, Navoo P, Collie D (2004) Meningiomas. Lancet 363(9420):1535–1543. https://doi.org/10.1016/S0140-6736(04)16153-9 - DOI - PubMed
    1. Schneider M, Güresir Á, Borger V, Hamed M, Racz A, Vatter H, Güresir E, Schuss P (2019) Preoperative tumor-associated epilepsy in patients with supratentorial meningioma: factors influencing seizure outcome after meningioma surgery. J Neurosurg:1–7. https://doi.org/10.3171/2019.7.JNS19455
    1. Kressner M, Arlt F, Riepl W, Meixensberger J (2018) Prognostic factors of microsurgical treatment of intracranial meningiomas - a multivariate analysis. PLoS One 13(10):e0202520. https://doi.org/10.1371/journal.pone.0202520 - DOI - PubMed - PMC
    1. Obesity: preventing and managing the global epidemic. Report of a WHO consultation (2000). World Health Organ Tech Rep Ser 894:i-xii, 1–253

MeSH terms

LinkOut - more resources