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Multicenter Study
. 2020;27(3):163-173.
doi: 10.1159/000506698. Epub 2020 Mar 26.

The Multicomponent, Multitarget Therapy SUC in Cats with Chronic Kidney Disease: A Multicenter, Prospective, Observational, Nonrandomized Cohort Study

Uta Brandenburg  1 , Gabriele Braun  2 , Peter Klein  3 , Erich Reinhart  4
Affiliations
Multicenter Study

The Multicomponent, Multitarget Therapy SUC in Cats with Chronic Kidney Disease: A Multicenter, Prospective, Observational, Nonrandomized Cohort Study

Uta Brandenburg et al. Complement Med Res. 2020.

Abstract
in English, German

Background: We compared the natural multicomponent, multitarget therapy SUC (Solidago compositum ad us. vet., Ubichinon compositum and Coenzyme compositum, Heel GmbH, Baden-Baden, Germany) to the well-known angiotensin-converting enzyme inhibitor benazepril in a prospective, observational, nonrandomized, two-arm cohort study of cats with chronic kidney disease (CKD). The objective was to assess the tolerability and the effectiveness of SUC in cats with CKD.

Material and methods: One hundred thirty-six cats were screened for CKD, and 70 cats were eligible for the study. Thirty-three cats were assigned to the SUC treatment, and 35 cats received benazepril. All cats were diagnosed with CKD. The follow-up period was 168 days. Response was assessed as an improved or stable serum creatinine from baseline to the end of the study. Additionally, a clinical summary score, as measure of quality of life, was evaluated.

Results: Serum creatinine remained close to baseline in both study groups with slightly improved values in the SUC group. The clinical summary score improved significantly in the SUC group on days 3, 7, 28, 56 and 112, but not on day 168.

Conclusions: Within the limitations of the study, the results carry implications for the usefulness of SUC as an interesting new treatment option for feline CKD. The results indicate that SUC might be more effective if given at least twice weekly.

Hintergrund: Es wurde die Multicomponent-Multitarget-Therapie SUC (Solidago compositum ad us. vet., Ubichinon compositum und Coenzym compositum, Heel GmbH, Baden-Baden, Deutschland) mit dem bekannten Angiotensin-Converting-Enzym-Inhibitor (ACEI) Benazepril in einer prospektiven, nichtrandomisierten, zweiarmigen Kohortenstudie an Katzen mit chronischer Nierenerkrankung (CNE) untersucht. Ziel war es, die Verträglichkeit und Wirksamkeit von SUC bei Katzen mit CNE zu beurteilen. Material und Methoden: Einhundertsechsunddreißig Katzen mit Verdacht auf CNE wurden untersucht, bei 70 Katzen wurde eine CNE diagnostiziert und diese wurden in die Studie aufgenommen. Dreiunddreißig Katzen wurden mit SUC therapiert und 35 Katzen erhielten Benazepril. Der Beobachtungszeitraum betrug 168 Tage. Das Ansprechen auf die Therapie wurde definiert als ein verbessertes bzw. ein stabiles Serumkreatinin am Ende der Studie im Vergleich zum Ausgangswert. Zusätzlich wurde zur Bewertung der Lebensqualität der Katzen ein klinischer Summenscore erfasst. Ergebnisse: Das Kreatinin blieb in beiden Studiengruppen nahezu unverändert, mit geringgradig niedrigeren Werten in der SUC-Gruppe. Der klinische Summenscore verbesserte sich in der SUC-Gruppe im Vergleich zur Benazepril-Gruppe signifikant an den Tagen 3, 28, 56 und 112, nicht aber am Tag 168. Schlussfolgerungen: Die Ergebnisse zeigen, dass SUC eine neuartige und gut verträgliche Behandlungsalternative zu ACEIs bei Katzen mit leichter bis mittelschwerer CNE darstellt. Die Ergebnisse deuten darauf hin, dass eine zweimal wöchentliche Therapie mit SUC effektiver sein könnte als eine Dosierung einmal pro Woche.

Keywords: Chronische Niereninsuffizienz; Coenzyme compositum; Katze; Solidago compositum ad us. vet.; Ubichinon compositum.

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Conflict of interest statement

U.B. has no competing interest to declare. G.B. is an employee of CRO Klifovet AG, who received consultancy fees from Heel GmbH. P.K. has received consultancy fees from Heel GmbH. E.R. is an employee of Heel GmbH.

Figures

Fig. 1
Fig. 1
Flowchart of the study.
Fig. 2
Fig. 2
Dosing scheme of SUC during the study.
Fig. 3
Fig. 3
Change in serum creatinine from baseline. Differences in serum creatinine between groups were not statistically significant at any time point. In the SUC group (■), serum creatinine was reduced until day 112.
Fig. 4
Fig. 4
Clinical summary score as indicator of quality of life. Mean summary score of all clinical and behavioral variables at baseline and during follow-up visits (days 3, 7, 28, 56, 112, 168). The dashed line displays values of the clinical summary score of the benazepril group, and the solid line displays the values for the SUC group. Horizontal lines represent standard errors. Higher scores indicate reduced quality of life; * p < 0.05: statistically significant difference between groups.
See this image and copyright information in PMC

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