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Review
. 2020 Mar 16:13:2289-2298.
doi: 10.2147/OTT.S182580. eCollection 2020.

Contemporary Multidisciplinary Management of Sinonasal Mucosal Melanoma

Shorook Na'ara  1   2 , Abhishek Mukherjee  3 , Salem Billan  2   4 , Ziv Gil  1   2
Affiliations
Review

Contemporary Multidisciplinary Management of Sinonasal Mucosal Melanoma

Shorook Na'ara et al. Onco Targets Ther. .

Abstract

Sinonasal mucosal melanoma (SNMM) is a rare tumor, comprising less than 10% of sinonasal malignancies. SNMM most frequently occurs in the nasal cavity (70%) and maxillary sinus (14%), typically as black patches. Overall, SNMM harbors a very poor prognosis; 5-year survival is less than 30%. Nasal cavity tumors confer a better prognosis than sinus melanoma. The primary management for SNMM is surgery, when feasible, followed by adjuvant radiotherapy. Recent studies suggest that immunotherapy may confer survival benefit to patients with advanced disease. The multidisciplinary team approach has been shown to optimize treatment, reduce costs, and minimize adverse events, while maximizing the chances for cure.

Keywords: head and neck; mucosal melanoma; multidisciplinary.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Survival rates of patients with sinonasal mucosal melanoma. (A) Five-year overall survival. (B) Five-year disease-free survival.
See this image and copyright information in PMC

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