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Clinical Trial
. 1977 Mar;74(3):1291-4.
doi: 10.1073/pnas.74.3.1291.

Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects

P Grevert, A Goldstein
Clinical Trial

Effects of naloxone on experimentally induced ischemic pain and on mood in human subjects

P Grevert et al. Proc Natl Acad Sci U S A. 1977 Mar.

Abstract

The hypothesis that painful stimuli activate the endogenous opioid (endorphin) system in humans was tested by examining the effect of the opiate antagonist naloxone on experimentally induced ischemic pain and on subjective mood ratings. Intravenous injections of saline or naloxone hydrochloride (2 and 10 mg) were administered under double-blind conditions to 12 subjects. Naloxone did not affect the pain ratings. However, a significant dose-related effect of naloxone on tension-anxiety was found, suggesting that the endorphins. like exogenously administered opiates, may have antianxiety properties.

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References

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