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. 2020 Feb 14:35:100656.
doi: 10.1016/j.nmni.2020.100656. eCollection 2020 May.

Pacemaker-associated infection caused by ST81/SCC mec IV methicillin-resistant, vancomycin-intermediate Staphylococcus aureus in Japan

M Sakurada  1 , H Sumi  1 , K Kaji  1 , N Kobayashi  2 , Y Sakai  3 , M S Aung  4 , N Urushibara  4 , N Kobayashi  4
Affiliations

Pacemaker-associated infection caused by ST81/SCC mec IV methicillin-resistant, vancomycin-intermediate Staphylococcus aureus in Japan

M Sakurada et al. New Microbes New Infect. .

Abstract

A 76-year-old Japanese man was admitted to hospital for treatment of fever and skin lesion at the implantation site of his pacemaker. During his hospitalization, vancomycin-intermediate Staphylococcus aureus (MIC 4 μg/mL) with reduced susceptibility to daptomycin was isolated from venous blood. This isolate was identified as methicillin-resistant S. aureus with SCCmec IV and was genotyped as sequence type 81, coa VIIa and spa type t7044, harbouring blaZ, aac(6')-aph(2″) and enterotoxin(-like) genes sea, seb, sek, sel, selx and selw. The patient was successfully treated with daptomycin, minocycline and sulfamethoxazole/trimethoprim. We describe the identification of sequence type 81/SCCmec IV vancomycin-intermediate S. aureus from pacemaker-associated septicaemia.

Keywords: Japan; MRSA; ST81; pacemaker-associated infection; vancomycin-intermediate Staphylococcus aureus(VISA).

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