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. 2020 Jun;111(6):877-887.
doi: 10.1007/s12185-020-02863-4. Epub 2020 Mar 26.

Nitrosourea, etoposide and cyclophosphamide followed by autologous stem cell transplantation for pediatric lymphoma patients

Jung Yoon Choi  1   2 , Hyoung Jin Kang  3   4 , Hong Yul An  1   2 , Kyung Taek Hong  1   2 , Hee Young Shin  1   2
Affiliations

Nitrosourea, etoposide and cyclophosphamide followed by autologous stem cell transplantation for pediatric lymphoma patients

Jung Yoon Choi et al. Int J Hematol. 2020 Jun.

Abstract

Treatment outcomes in pediatric lymphoma have improved substantially over the past 2 decades; however, the prognosis for patients with high risk or relapsed disease remains poor. We evaluated outcomes of high-dose chemotherapy (HDC) and autologous stem cell transplantation (auto-SCT) in 56 pediatric lymphoma patients. Patients received nitrosourea (51 BCNU; 5 ACNU), etoposide, and cyclophosphamide (BEC; AEC). Median age at HDC/auto-SCT was 12 years (range 2-17 years). Forty-four patients underwent HDC/auto-SCT because they did not achieve complete remission after induction chemotherapy. Eight patients showed relapse and four NK/T-cell lymphoma patients also underwent HDC/auto-SCT. BCNU pneumonitis was diagnosed in nine (16.0%) patients. Eight (14.3%) relapsed after HDC/auto-SCT. Treatment-related mortality occurred in three cases. Five-year event-free survival and overall survival rates were 74.8% [72.7% non-Hodgkin's lymphoma (NHL); 83.3% Hodgkin's disease (HD); 72.7%] and 83.6% (81.6% NHL; 91.7% HD), respectively. HDC/auto-SCT with BEC or AEC regimen for pediatric high-risk lymphoma patients showed feasible outcomes. However, treatment modifications are warranted to reduce relapse and toxicity.

Keywords: Autologous stem cell transplantation; Carmustine; Lymphoma; Pediatric.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Survival of pediatric lymphoma patients who underwent high-dose chemotherapy and autologous stem cell transplantation. a Five-year event-free survival (EFS) was 74.8%. b Five-year overall survival (OS) was 83.6%. c Five-year EFS for lymphoblastic lymphoma (LBL), Burkitt lymphoma/diffuse large B-cell lymphoma (BL/DLBCL), anaplastic large cell lymphoma (ALCL) and Hodgkin’s disease (HD) was 76.2%, 72.7%, 70.0% and 83.3%, respectively. d Five-year OS for LBL, BL/DLBCL, ALCL and HD was 74.1%, 90.0%, 80.0% and 91.7%, respectively
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References

    1. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES. The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood. 2011;117(19):5019–5032. doi: 10.1182/blood-2011-01-293050. - DOI - PMC - PubMed
    1. Sandlund JT, Downing JR, Crist WM. Non-Hodgkin’s lymphoma in childhood. N Engl J Med. 1996;334(19):1238–1248. doi: 10.1056/NEJM199605093341906. - DOI - PubMed
    1. Gerrard M, Cairo MS, Weston C, Auperin A, Pinkerton R, Lambilliote A, et al. Excellent survival following two courses of COPAD chemotherapy in children and adolescents with resected localized B-cell non-Hodgkin’s lymphoma: results of the FAB/LMB 96 international study. Br J Haematol. 2008;141(6):840–847. doi: 10.1111/j.1365-2141.2008.07144.x. - DOI - PubMed
    1. Lowe EJ, Sposto R, Perkins SL, Gross TG, Finlay J, Zwick D, et al. Intensive chemotherapy for systemic anaplastic large cell lymphoma in children and adolescents: final results of Children’s Cancer Group Study 5941. Pediatr Blood Cancer. 2009;52(3):335–339. doi: 10.1002/pbc.21817. - DOI - PMC - PubMed
    1. Patte C, Auperin A, Gerrard M, Michon J, Pinkerton R, Sposto R, et al. Results of the randomized international FAB/LMB96 trial for intermediate risk B-cell non-Hodgkin lymphoma in children and adolescents: it is possible to reduce treatment for the early responding patients. Blood. 2007;109(7):2773–2780. doi: 10.1182/blood-2006-07-036673. - DOI - PMC - PubMed

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