Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 May;33(3):e13331.
doi: 10.1111/dth.13331. Epub 2020 Apr 25.

Oral propranolol administration is effective for infantile hemangioma in late infancy: A retrospective cohort study

Khalaf Kridin  1 , Nadav Pam  1 , Reuven Bergman  1   2 , Ziad Khamaysi  1   2
Affiliations

Oral propranolol administration is effective for infantile hemangioma in late infancy: A retrospective cohort study

Khalaf Kridin et al. Dermatol Ther. 2020 May.

Abstract

The highest efficacy of oral propranolol is for infantile hemangioma (IH) in the proliferative phase. Evaluation of the effectiveness of oral propranolol is less established when it is administered in late infancy following the proliferative phase. We aimed to assess the clinical outcomes of pediatric patients managed by oral propranolol beyond the proliferative phase of IH. A retrospective cohort study in a tertiary health care referral center was conducted to track all patients with IH receiving systemic propranolol following the proliferative phase. Twenty-eight eligible patients were managed by 2 to 3 mg/kg per day of oral propranolol for IH beyond the proliferative phase, defined at 9 months of age. The mean age at the initiation of propranolol was estimated at 11.25 (SD 2.24) months. All eligible patients experienced some degree of clinical resolution, with the average improvement rate being estimated at 77.1% (SD 16.1). Comparable results were achieved among patients who were placed on propranolol at an age older than 12 months and those managed between the age of 9 and 12 months. No serious adverse events were observed during the follow-up duration. In conclusion, oral propranolol is a safe and effective treatment for patients with IH initiating this agent beyond the proliferative phase.

Keywords: infantile hemangioma; late infancy; postproliferative; propranolol.

PubMed Disclaimer

References

REFERENCES

    1. Krowchuk DP, Frieden IJ, Mancini AJ, et al. Clinical practice guideline for the management of infantile hemangiomas. Pediatrics. 2019;143:e20183475. https://doi.org/10.1542/peds.2018-3475.
    1. Léauté-Labrèze C, De La Roque ED, Hubiche T, Boralevi F, Thambo JB, Taïeb A. Propranolol for severe hemangiomas of infancy. N Engl J Med. 2008;358:2649-2651. https://doi.org/10.1056/NEJMc0708819.
    1. Novoa M, Baselga E, Beltran S, et al. Interventions for infantile haemangiomas of the skin. Cochrane Database Syst Rev. 2018;2018(4):CD006545. https://doi.org/10.1002/14651858.CD006545.pub3.
    1. Léauté-Labrèze C, Hoeger P, Mazereeuw-Hautier J, et al. A randomized, controlled trial of oral propranolol in infantile hemangioma. N Engl J Med. 2014;372:735-746. https://doi.org/10.1056/NEJMoa1404710.
    1. Chang LC, Haggstrom AN, Drolet BA, et al. Growth characteristics of infantile hemangiomas: implications for management. Pediatrics. 2008;122:360-367. https://doi.org/10.1542/peds.2007-2767.

LinkOut - more resources