Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;80(1):61.
doi: 10.1186/s41936-019-0131-1. Epub 2019 Nov 21.

Influenza A (H1N1) virus infection and TNF-308, IL6, and IL8 polymorphisms in Egyptian population: a case-control study

Shaimaa Moustafa Elsayed  1 , Omayma Mohamed Hassanein  2 , Nagwa Hassan Ali Hassan  3
Affiliations

Influenza A (H1N1) virus infection and TNF-308, IL6, and IL8 polymorphisms in Egyptian population: a case-control study

Shaimaa Moustafa Elsayed et al. J Basic Appl Zool. 2019.

Abstract

Background: The importance of influenza is increasing mainly because of the appearance of novel pandemic strains such as swine and avian. Each year, influenza has spread around the world causing about 250,000-500,000 deaths and more than 5 million cases of severe illness.The objective is as follows: evaluating the outcomes of patients with influenza A (H1N1) virus in relation to certain TNF-308, IL6, and IL8 polymorphisms and identifying the associated factors with the severe outcome.

Subject and methods: This is a case-control study. The cases were patients confirmed by real-time polymerase chain reaction (RT-PCR) to be influenza A (H1N1) virus infected. The controls were healthy individuals. Medical history and outcome of the disease was registered. In all study participants, polymorphisms of TNF rs1800629, IL6 rs18138879, and IL8 rs4073; odds ratio (OR); and the 95% confidence interval (95% CI) were calculated.

Results: Infection with influenza A (H1N1) virus was associated more with the following genotypes: TNF-308 AA (OR = 4.041; 95% CI = 1.215-13.4) and IL8 AA (OR = 3.273; 95% CI = 1.372-7.805). According to our study results, HCV (OR = 3.2, 95% CI 1.2-8.5), renal disease (OR = 3.4, 95% CI 0.9-13.6), cancer (OR = 3.1, 95% CI 0.3-31.1), TB (OR = 8.4, 95% CI 1.8-39.7), ICU (OR = 2.9, 95%1.2-7.1), and mortality (OR = 7.9, 95% CI 0.9-67.4) are considered as risk factors for influenza A (H1N1)-infected patients.

Conclusions: Our findings concluded that TNF-308 (AA) and IL8 (AA) polymorphisms may increase the susceptibility to be infected with H1N1influenza virus.

Keywords: Cytokine polymorphisms; IL6 and IL8; Influenza; TNF-308.

PubMed Disclaimer

Conflict of interest statement

Competing interestsThe authors declare that they have no competing interests.

References

    1. Antonopoulou A, Baziaka F, Tsaganos T, Raftogiannis M, Koutoukas P. Role of tumor necrosis factor gene single nucleotide polymorphisms in the natural course of 2009 influenza A H1N1 virus infection. International Journal of Infectious Diseases. 2012;16(3):e204–e208. doi: 10.1016/j.ijid.2011.11.012. - DOI - PubMed
    1. Bermejo-Martin JF, De Lejarazu RO, Pumarola T, Rello J, Almansa R, Ramirez P, et al. Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Critical Care. 2009;13:R201. doi: 10.1186/cc8208. - DOI - PMC - PubMed
    1. BinSaeed AA. Characteristics of pandemic influenza A (H1N1) infection in patients presenting to a university hospital in Riyadh, Saudi Arabia. Annals of Saudi Medicine. 2010;30(1):59–62. doi: 10.5144/0256-4947.59377. - DOI - PMC - PubMed
    1. Cao B, Li XW, Mao Y, Wang J, Lu HZ, Chen YS, et al. National Influenza A Pandemic (H1N1) 2009 Clinical Investigation Group of China: Clinical features of the initial cases of 2009 pandemic influenza A (H1N1) virus infection in China. The New England Journal of Medicine. 2009;361(26):2507–2517. doi: 10.1056/NEJMoa0906612. - DOI - PubMed
    1. Cheng CH, Lee YS, Tsau YK, et al. Genetic polymorphisms and susceptibility to parenchymal renal infection among pediatric patient. The Pediatric Infectious Disease Journal. 2011;30:309–314. doi: 10.1097/INF.0b013e3181ff84ff. - DOI - PubMed

LinkOut - more resources