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. 2020 Jun;25(6):660-665.
doi: 10.1111/tmi.13395. Epub 2020 Apr 16.

Tropical pyomyositis: an update

Adebayo Shittu  1   2 , Stefanie Deinhardt-Emmer  3 , Jonathan Vas Nunes  4   5 , Silke Niemann  2 , Martin P Grobusch  5   6 , Frieder Schaumburg  2
Affiliations
Free article

Tropical pyomyositis: an update

Adebayo Shittu et al. Trop Med Int Health. 2020 Jun.
Free article

Abstract
in English, French

Tropical pyomyositis (TP) is a life-threatening bacterial infection of the skeletal muscle that occurs particularly among children, young adults and those with immunocompromised conditions. The appropriate diagnosis and treatment are often delayed due to its non-specific signs, leading to fatal consequences. Staphylococcus aureus, especially methicillin-susceptible S. aureus, is responsible for most TP cases. However, other bacteria (i.e. streptococci, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) have been reported. This narrative review provides an update on the epidemiology and clinical course of TP. A special focus is laid on the role of toxins (i.e. Panton-Valentine Leucocidin and α-toxin) in the pathogenesis of TP and their implication for the clinical management of infection.

La pyomyosite tropicale (TP) est une infection bactérienne potentiellement mortelle du muscle squelettique qui survient particulièrement chez les enfants, les jeunes adultes et les personnes immunodéprimées. Le diagnostic et le traitement appropriés sont souvent retardés en raison de ses signes non spécifiques, entraînant des conséquences fatales. Staphylococcus aureus, en particulier S. aureus sensible à la méthicilline, est responsable de la plupart des cas de TP. Cependant, d'autres bactéries (ex: streptocoques, Pseudomonas aeruginosa, Escherichia coli, Klebsiella spp., Candida spp., Mycobacterium spp.) ont été rapportées. Cette revue narrative fournit une mise à jour sur l'épidémiologie et l'évolution clinique du TP. Un accent particulier est mis sur le rôle des toxines (la Leukocidine de Panton-Valentine et l’α-toxine) dans la pathogenèse du TP et leur implication pour la prise en charge clinique de l'infection.

Keywords: Staphylococcus aureus; Staphylococcus aureus; clinical course; epidemiology; pathogenesis; pathogenèse; pyomyosite tropicale; review; revue; tropical pyomyositis; épidémiologie; évolution clinique.

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References

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