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. 2020 Jan-Dec;91(1):e13344.
doi: 10.1111/asj.13344.

Effects of supplementation with β-carotene on the growth performance and intestinal mucosal barriers in layer-type cockerels

Junnan Hui  1 , Lingxi Li  1 , Ruonan Li  1 , Min Wu  1 , Yu Yang  1 , Jinghui Wang  2 , Yuanyuan Fan  3 , Xin Zheng  1
Affiliations

Effects of supplementation with β-carotene on the growth performance and intestinal mucosal barriers in layer-type cockerels

Junnan Hui et al. Anim Sci J. 2020 Jan-Dec.

Erratum in

  • Corrigendum.
    [No authors listed] [No authors listed] Anim Sci J. 2020 Jan-Dec;91(1):e13444. doi: 10.1111/asj.13444. Anim Sci J. 2020. PMID: 37002566 No abstract available.

Abstract

β-carotene is a robust modulator of mucosal barriers, and it can amplify the immunoglobulin A (IgA) response via the retinoic acid (RA)-mediated pathway. We investigated the influence of β-carotene on intestinal barriers in layer-type cockerels. In this study, β-carotene has a positive influence on growth performance and intestinal morphology. β-carotene remarkably enhanced serum secretory immunoglobulin A (sIgA) levels, jejunal mucosal sIgA, and IgA concentrations. β-Carotene significantly enhanced mRNA expression levels of IgA, CC chemokine receptor-9 (CCR9), polymeric immunoglobulin receptor (pIgR), and retinoic acid receptor α (RARα) in the ileal tissues and pIgR in the jejunal tissues. β-Carotene improves mRNA expression of intestinal barrier-related proteins including: mucin-2 (MUC-2), zonula occludens-2 (ZO-2), occludins (OCLN), and zonula occludens-1 (ZO-1) in the ileal tissues. Moreover, β-carotene decreased the levels of Escherichia coli and elevates the levels of Lactobacillus. The results indicate that β-carotene can promote growth performance and contribute to the gradual development of intestinal barriers in Hyline Brown chicks. This study enriches our knowledge about the effects of β-carotene on intestinal barrier and highlights a theoretical basis of β-carotene application in the poultry industry.

Keywords: Hyline Brown chicks; RA-mediated pathway; intestinal barriers; intestinal microbiota; β-carotene.

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References

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