Here to Heal: Mucosal CD74 Signaling in Colitis

Affiliations

¹ Center for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
² Center for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: cpothoulakis@mednet.ucla.edu.

Editorial

Jill M Hoffman et al. Cell Mol Gastroenterol Hepatol. 2020.

. 2020;10(1):197-198.

doi: 10.1016/j.jcmgh.2020.03.002. Epub 2020 Mar 24.

¹ Center for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
² Center for Inflammatory Bowel Diseases, Vatche and Tamar Manoukian, Division of Digestive Diseases, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California. Electronic address: cpothoulakis@mednet.ucla.edu.

No abstract available

Comment on

CD74 Signaling Links Inflammation to Intestinal Epithelial Cell Regeneration and Promotes Mucosal Healing.
Farr L, Ghosh S, Jiang N, Watanabe K, Parlak M, Bucala R, Moonah S. Farr L, et al. Cell Mol Gastroenterol Hepatol. 2020;10(1):101-112. doi: 10.1016/j.jcmgh.2020.01.009. Epub 2020 Jan 28. Cell Mol Gastroenterol Hepatol. 2020. PMID: 32004754 Free PMC article.

1. Wagner F., Mansfield J., Geier C., Dash A., Wang Y., Li C., Lekkerkerker A., Lu T. P420 A randomised, observer-blinded phase Ib multiple, ascending dose study of UTTR1147A, an IL-22Fc fusion protein, in healthy volunteers and ulcerative colitis patients. J Crohns Colitis. 2020;14(Suppl 1):S382–S383.
1. Farr L., Ghosh S., Jiang N., Watanabe K., Parlak M., Bucala R., Moonah S. CD74 signaling links inflammation to intestinal epithelial cell regeneration and promotes mucosal healing. Cell Mol Gastroenterol Hepatol. 2020;10:101–112. - PMC - PubMed
1. Gil-Yarom N., Radomir L., Sever L., Kramer M.P., Lewinsky H., Bornstein C., Blecher-Gonen R., Barnett-Itzhaki Z., Mirkin V., Friedlander G., Shvidel L., Herishanu Y., Lolis E.J., Becker-Herman S., Amit I., Shachar I. CD74 is a novel transcription regulator. Proc Natl Acad Sci U S A. 2017;114:562–567. - PMC - PubMed
1. Lawrance I.C., Fiocchi C., Chakravarti S. Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes. Hum Mol Genet. 2001;10:445–456. - PubMed
1. Parikh K., Antanaviciute A., Fawkner-Corbett D., Jagielowicz M., Aulicino A., Lagerholm C., Davis S., Kinchen J., Chen H.H., Alham N.K., Ashley N., Johnson E., Hublitz P., Bao L., Lukomska J., Andev R.S., Bjorklund E., Kessler B.M., Fischer R., Goldin R., Koohy H., Simmons A. Colonic epithelial cell diversity in health and inflammatory bowel disease. Nature. 2019;567:49–55. - PubMed