Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Jul:140:109686.
doi: 10.1016/j.mehy.2020.109686. Epub 2020 Mar 21.

Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2

Affiliations

Renin-angiotensin system: The unexpected flaw inside the human immune system revealed by SARS-CoV-2

Luca Roncati et al. Med Hypotheses. 2020 Jul.
No abstract available

PubMed Disclaimer

Figures

Fig. 1
Fig. 1
After a chronic assumption of ACE inhibitors and AII receptor antagonists a normal cell (on the left) could be hypothetically rearranged into one with higher expression of ACE2 receptors (on the right), so turning particularly receptive and vulnerable to SARS-CoV-2.

Comment in

References

    1. Boehm M., Nabel E.G. Angiotensin-converting enzyme 2–a new cardiac regulator. N Engl J Med. 2002;347(22):1795–1797. - PubMed
    1. Zhang H., Penninger J.M., Li Y., Zhong N. Angiotensin-converting enzyme 2 (ACE2) as a SARS-CoV-2 receptor: molecular mechanisms and potential therapeutic target. Intensive Care Med. 2020 doi: 10.1007/s00134-020-05985-9. - DOI - PMC - PubMed
    1. Huang M.L., Li X., Meng Y., Xiao B. Upregulation of angiotensin-converting enzyme (ACE) 2 in hepatic fibrosis by ACE inhibitors. Clin Exp Pharmacol Physiol. 2010;37(1):1–6. - PubMed
    1. Ferrario C.M., Jessup J., Chappell M.C., Averill D.B. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111(20):2605–2610. - PubMed