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. 2020 May 7;15(5):714-716.
doi: 10.2215/CJN.03530320. Epub 2020 Mar 27.

Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19

Matthew A Sparks  1 , Andrew South  2 , Paul Welling  3 , J Matt Luther  4 , Jordana Cohen  5 , James Brian Byrd  6 , Louise M Burrell  7 , Daniel Batlle  8 , Laurie Tomlinson  9 , Vivek Bhalla  10 , Michelle N Rheault  11 , María José Soler  12 , Sundar Swaminathan  13 , Swapnil Hiremath  14
Affiliations

Sound Science before Quick Judgement Regarding RAS Blockade in COVID-19

Matthew A Sparks et al. Clin J Am Soc Nephrol. .
No abstract available

Keywords: ACE inhibitors; Angiotensin-Converting Enzyme Inhibitors; COVID-19; Renin-Angiotensin System; angiotensin; hypertension; renin angiotensin system; severe acute respiratory syndrome coronavirus 2; virology.

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Figures

Figure 1.
Figure 1.
Potential effect of angiotensin-converting enzyme inhibitors (ACEis) and angiotensin receptor blockers (ARBs) on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)–induced alterations to renin-angiotensin system pathways. SARS-CoV-2 binds to angiotensin-converting enzyme 2 (ACE2) via its spike protein and induces internalization and shedding of ACE2, leading to increased angiotensin II (Ang II) and decreased angiotensin (1–7) [Ang-(1–7)] with net increase in inflammation and fibrosis (red) relative to anti-inflammatory and antifibrotic actions (blue). In the left panel, there is no ACEi or ARB; in the right panel, ACEi and/or ARB treatment could diminish effects of Ang II and increase Ang-(1–7) effects, leading to attenuated inflammation and fibrosis. The dashed inset in the right panel represents a theoretical increase in cell membrane expression of ACE2 with ACEi and/or ARB use. AT1R, type 1 angiotensin receptor; AT2R, type 2 angiotensin receptor; MasR, Mas receptor.
See this image and copyright information in PMC

References

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