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. 2020 Sep;92(9):1556-1561.
doi: 10.1002/jmv.25789. Epub 2020 Apr 10.

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia

Siyu Chen  1 , E Liao  2 , Dongmei Cao  2 , Ying Gao  2 , Guoqiang Sun  2 , Yong Shao  1
Affiliations

Clinical analysis of pregnant women with 2019 novel coronavirus pneumonia

Siyu Chen et al. J Med Virol. 2020 Sep.

Abstract

The aim is to evaluate pregnant women infected with coronavirus disease 2019 (COVID-19) and provide help for clinical prevention and treatment. All five cases of pregnant women confirmed COVID-19 were collected among patients who admitted to the Maternal and Child Hospital of Hubei Province between January 20 and February 10, 2020. All patients, aging from 25 to 31 years old, had the gestational week from 38th weeks to 41st weeks. All pregnant women did not have an antepartum fever but developed a low-grade fever (37.5℃-38.5℃) within 24 hours after delivery. All patients had normal liver and renal function, two patients had elevated plasma levels of the myocardial enzyme. Unusual chest imaging manifestations, featured with ground-grass opacity, were frequently observed in bilateral (three cases) or unilateral lobe (two cases) by computed tomography (CT) scan. All labors smoothly processed, the Apgar scores were 10 points 1 and 5 minutes after delivery, no complications were observed in the newborn. Pregnancy and perinatal outcomes of patients with COVID-19 should receive more attention. It is probable that pregnant women diagnosed with COVID-19 have no fever before delivery. Their primary initial manifestations were merely low-grade postpartum fever or mild respiratory symptoms. Therefore, the protective measures are necessary on admission; the instant CT scan and real-time reverse-transcriptase polymerase-chain-reaction assay should be helpful in early diagnosis and avoid cross-infection on the occasion that patients have fever and other respiratory signs.

Keywords: COVID-19; clinical manifestations; labor; pregnancy.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Chest computed tomography (CT) image of the pregnant women with coronavirus disease 2019 (COVID‐19). Chest CT images of patient1 showed ground‐glass opacity in left lung on day 1 after symptom onset. Chest CT images of patient 2 showed ground‐glass opacity in both lungs on day 1 after symptom onset. Chest CT images of patient 3 showed ground‐glass opacity in the right lung on day 1 after symptom onset. Chest CT images of patient 4 showed ground‐glass opacity in the right lung on day 1 after symptom onset. Chest CT images of patient 5 showed ground‐glass opacity in both lungs on day 1 after symptom onset
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