Antihypertensive drugs and risk of COVID-19?

doi:10.1016/S2213-2600(20)30153-3

Comment

. 2020 May;8(5):e30-e31.

doi: 10.1016/S2213-2600(20)30153-3. Epub 2020 Mar 26.

Antihypertensive drugs and risk of COVID-19?

Christopher J Tignanelli¹, Nicholas E Ingraham², Matthew A Sparks³, Ronald Reilkoff², Tamara Bezdicek⁴, Bradley Benson⁵, Timothy Schacker⁶, Jeffrey G Chipman⁷, Michael A Puskarich⁸

Affiliations

¹ Department of Surgery, Division of Acute Care Surgery, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: ctignane@umn.edu.
² Department of Medicine, Division of Pulmonary and Critical Care, University of Minnesota, Minneapolis, MN 55455, USA.
³ Department of Medicine, Division of Nephrology, Duke University, Durham, NC, USA.
⁴ Department of Pharmacy, Fairview Southdale, Minnesota, MN, USA.
⁵ Department of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
⁶ Department of Medicine, Division of Medicine and Infectious Disease, University of Minnesota, Minneapolis, MN 55455, USA.
⁷ Department of Surgery, Division of Acute Care Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
⁸ Department of Emergency Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA.

PMID: 32222166
PMCID: PMC7194709
DOI: 10.1016/S2213-2600(20)30153-3

Comment

Antihypertensive drugs and risk of COVID-19?

Christopher J Tignanelli et al. Lancet Respir Med. 2020 May.

. 2020 May;8(5):e30-e31.

doi: 10.1016/S2213-2600(20)30153-3. Epub 2020 Mar 26.

Authors

Christopher J Tignanelli¹, Nicholas E Ingraham², Matthew A Sparks³, Ronald Reilkoff², Tamara Bezdicek⁴, Bradley Benson⁵, Timothy Schacker⁶, Jeffrey G Chipman⁷, Michael A Puskarich⁸

Affiliations

¹ Department of Surgery, Division of Acute Care Surgery, University of Minnesota, Minneapolis, MN 55455, USA; Institute for Health Informatics, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: ctignane@umn.edu.
² Department of Medicine, Division of Pulmonary and Critical Care, University of Minnesota, Minneapolis, MN 55455, USA.
³ Department of Medicine, Division of Nephrology, Duke University, Durham, NC, USA.
⁴ Department of Pharmacy, Fairview Southdale, Minnesota, MN, USA.
⁵ Department of Medicine, Division of General Internal Medicine, University of Minnesota, Minneapolis, MN 55455, USA.
⁶ Department of Medicine, Division of Medicine and Infectious Disease, University of Minnesota, Minneapolis, MN 55455, USA.
⁷ Department of Surgery, Division of Acute Care Surgery, University of Minnesota, Minneapolis, MN 55455, USA.
⁸ Department of Emergency Medicine, University of Minnesota, Minneapolis, MN 55455, USA; Department of Emergency Medicine, Hennepin County Medical Center, Minneapolis, MN, USA.

PMID: 32222166
PMCID: PMC7194709
DOI: 10.1016/S2213-2600(20)30153-3

No abstract available

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Figures

**Figure**
Potential therapeutic options to address AT1 receptor-mediated lung injury in patients with COVID-19 (A) Mechanism in a healthy individual. (B) Mechanism in an individual with COVID-19. AT1=angiotensin 1. AT2=angiotensin 2. ACE1=angiotensin converting enzyme 1. ACE2=angiotensin converting enzyme 2. AT1R=type 1 angiotensin 2 receptor. AT_1-7=heptapeptide angiotensin(1-7). ACEI=angiotensin-converting enzyme inhibitor. ARB=angiotensin receptor blocker. COVID-19=coronavirus disease 2019. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.

See this image and copyright information in PMC

Comment on

Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
Fang L, Karakiulakis G, Roth M. Fang L, et al. Lancet Respir Med. 2020 Apr;8(4):e21. doi: 10.1016/S2213-2600(20)30116-8. Epub 2020 Mar 11. Lancet Respir Med. 2020. PMID: 32171062 Free PMC article. No abstract available.

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References

1. Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30116-8. published online March 11. - DOI - PMC - PubMed
1. Ramchand J, Patel SK, Srivastava PM, Farouque O, Burrell LM. Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease. PLoS One. 2018;13 - PMC - PubMed
1. Walters TE, Kalman JM, Patel SK, Mearns M, Velkoska E, Burrell LM. Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. Europace. 2017;19:1280–1287. - PubMed
1. Wang D, Hu B, Hu C. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–1069. - PMC - PubMed
1. Li W, Moore MJ, Vasilieva N. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450–454. - PMC - PubMed

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[1] Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30116-8. published online March 11. - DOI - PMC - PubMed

[2] Fang L, Karakiulakis G, Roth M. Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? Lancet Respir Med. 2020 doi: 10.1016/S2213-2600(20)30116-8. published online March 11. - DOI - PMC - PubMed

[3] Ramchand J, Patel SK, Srivastava PM, Farouque O, Burrell LM. Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease. PLoS One. 2018;13 - PMC - PubMed

[4] Ramchand J, Patel SK, Srivastava PM, Farouque O, Burrell LM. Elevated plasma angiotensin converting enzyme 2 activity is an independent predictor of major adverse cardiac events in patients with obstructive coronary artery disease. PLoS One. 2018;13 - PMC - PubMed

[5] Walters TE, Kalman JM, Patel SK, Mearns M, Velkoska E, Burrell LM. Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. Europace. 2017;19:1280–1287. - PubMed

[6] Walters TE, Kalman JM, Patel SK, Mearns M, Velkoska E, Burrell LM. Angiotensin converting enzyme 2 activity and human atrial fibrillation: increased plasma angiotensin converting enzyme 2 activity is associated with atrial fibrillation and more advanced left atrial structural remodelling. Europace. 2017;19:1280–1287. - PubMed

[7] Wang D, Hu B, Hu C. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–1069. - PMC - PubMed

[8] Wang D, Hu B, Hu C. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323:1061–1069. - PMC - PubMed

[9] Li W, Moore MJ, Vasilieva N. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450–454. - PMC - PubMed

[10] Li W, Moore MJ, Vasilieva N. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. 2003;426:450–454. - PMC - PubMed

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Antihypertensive drugs and risk of COVID-19?

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Antihypertensive drugs and risk of COVID-19?

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