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. 2020 Sep;92(9):1637-1640.
doi: 10.1002/jmv.25794. Epub 2020 Apr 10.

Genomic characterization and phylogenetic analysis of SARS-COV-2 in Italy

Gianguglielmo Zehender  1   2   3 , Alessia Lai  1   2 , Annalisa Bergna  1 , Luca Meroni  4 , Agostino Riva  4 , Claudia Balotta  1 , Maciej Tarkowski  1 , Arianna Gabrieli  1 , Dario Bernacchia  4 , Stefano Rusconi  1   4 , Giuliano Rizzardini  5 , Spinello Antinori  1   4 , Massimo Galli  1   2   4
Affiliations

Genomic characterization and phylogenetic analysis of SARS-COV-2 in Italy

Gianguglielmo Zehender et al. J Med Virol. 2020 Sep.

Abstract

This report describes the isolation, molecular characterization, and phylogenetic analysis of the first three complete genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from three patients involved in the first outbreak of COVID-19 in Lombardy, Italy. Early molecular epidemiological tracing suggests that SARS-CoV-2 was present in Italy weeks before the first reported cases of infection.

Keywords: COVID-19; complete genomes of SARS-CoV-2; phylogenetic analysis.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Root‐to‐tip regression analysis of the 161 SARS‐CoV‐2 sequences aligned
Figure 2
Figure 2
Dated tree of 161 SARS‐CoV‐2 sequences showing statistically significant support for clades along the branches (posterior probability >0.7). Clade A containing the Italian strains is highlighted in red. The patients characterized in this study are indicated by a symbol. The table shows the time of the most recent common ancestor (tMRCA) estimates and 95% high posterior density of the significant clade A nodes. SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2
See this image and copyright information in PMC

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