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. 2020 Sep;92(9):1562-1566.
doi: 10.1002/jmv.25797. Epub 2020 Apr 8.

Phylogenetic analysis of the first four SARS-CoV-2 cases in Chile

Andrés E Castillo  1 , Bárbara Parra  1 , Paz Tapia  1 , Alejandra Acevedo  2 , Jaime Lagos  1 , Winston Andrade  2 , Loredana Arata  1 , Gabriel Leal  2 , Gisselle Barra  1 , Carolina Tambley  2 , Javier Tognarelli  1 , Patricia Bustos  2 , Soledad Ulloa  1 , Rodrigo Fasce  2 , Jorge Fernández  1
Affiliations

Phylogenetic analysis of the first four SARS-CoV-2 cases in Chile

Andrés E Castillo et al. J Med Virol. 2020 Sep.

Abstract

The current pandemic caused by the new coronavirus is a worldwide public health concern. To aboard this emergency, and like never before, scientific groups around the world have been working in a fast and coordinated way to get the maximum of information about this virus when it has been almost 3 months since the first cases were detected in Wuhan province in China. The complete genome sequences of around 450 isolates are available, and studies about similarities and differences among them and with the close related viruses that caused similar epidemics in this century. In this work, we studied the complete genome of the first four cases of the new coronavirus disease in Chile, from patients who traveled to Europe and Southeast Asia. Our findings reveal at least two different viral variants entries to Chilean territory, coming from Europe and Asia. We also sub-classified the isolates into variants according to punctual mutations in the genome. Our work contributes to global information about transmission dynamics and the importance to take control measures to stop the spread of the infection.

Keywords: COVID-19; SARS-CoV-2; phylogeny.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Phylogenetic tree with Maximum Composite Likelihood distance, representing 222 complete genomes including the four Chilean isolates. The name of the isolates were colored according to the variants as follows: S (blue), G (red), V (purple), unclassified variants (green), and the main clades were highlighted. Chilean strains are marked over the cladogram in the S and G variant clades
See this image and copyright information in PMC

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