Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19

Luca Steardo^{1

2}, Luca Steardo Jr³, Robert Zorec^{4

5}, Alexei Verkhratsky^{6

7}

Affiliations

¹ Fortunato University, Benevento, Italy.
² Sapienza University, Rome, Italy.
³ University Magna Graecia, Catanzaro, Italy.
⁴ Clica BIOMEDICAL, Ljubljana, Slovenia.
⁵ Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
⁶ Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
⁷ Achucarro Center for Neuroscience, IKERBASQUE, Bilbao, Spain.

Review

Luca Steardo et al. Acta Physiol (Oxf). 2020 Jul.

. 2020 Jul;229(3):e13473.

doi: 10.1111/apha.13473. Epub 2020 Apr 11.

Luca Steardo^{1

2}, Luca Steardo Jr³, Robert Zorec^{4

5}, Alexei Verkhratsky^{6

7}

¹ Fortunato University, Benevento, Italy.
² Sapienza University, Rome, Italy.
³ University Magna Graecia, Catanzaro, Italy.
⁴ Clica BIOMEDICAL, Ljubljana, Slovenia.
⁵ Laboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
⁶ Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK.
⁷ Achucarro Center for Neuroscience, IKERBASQUE, Bilbao, Spain.

No abstract available

Conflict of interest statement

No conflict of interest to declare.

1. Gaunt ER, Hardie A, Claas EC, Simmonds P, Templeton KE. Epidemiology and clinical presentations of the four human coronaviruses 229E, HKU1, NL63, and OC43 detected over 3 years using a novel multiplex real‐time PCR method. J Clin Microbiol. 2010;48(8):2940‐2947. - PMC - PubMed
1. Li YC, Bai WZ, Hashikawa T. The neuroinvasive potential of SARS‐CoV2 may play a role in the respiratory failure of COVID‐19 patients. J Med Virol. 2020. 10.1002/jmv.25728. [Epub ahead of print]. - DOI - PMC - PubMed
1. Dube M, Le Coupanec A, Wong AHM, Rini JM, Desforges M, Talbot PJ. Axonal transport enables neuron‐to‐neuron propagation of human coronavirus OC43. J Virol. 2018;92(17):e00404. - PMC - PubMed
1. Li Y‐C, Bai W‐Z, Hirano N, et al. Neurotropic virus tracing suggests a membranous‐coating‐mediated mechanism for transsynaptic communication. J Comp Neurol. 2013;521(1):203‐212. - PMC - PubMed
1. Talbot PJ, Ekande S, Cashman NR, Mounir S, Stewart JN. Neurotropism of human coronavirus 229E. Adv Exp Med Biol. 1993;342:339‐346. - PubMed