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. 2020 Dec 20;26(6):311-319.
doi: 10.5761/atcs.oa.20-00010. Epub 2020 Mar 27.

Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer

Yoshimasa Tokunaga  1 , Yusuke Kita  1 , Taku Okamoto  1
Affiliations

Analysis of Risk Factors for Bronchopleural Fistula after Surgical Treatment of Lung Cancer

Yoshimasa Tokunaga et al. Ann Thorac Cardiovasc Surg. .

Abstract

Purpose: Bronchopleural fistula (BPF) is a potential serious complication of lobectomy or more radical surgery for non-small-cell lung cancer (NSCLC). We aimed to evaluate the risk factors for BPF.

Methods: The study cohort comprised 635 patients who had undergone lobectomy or more radical surgery for NSCLC from March 2005 to December 2017. We examined the following risk factors for BPF: surgical procedure, medical history, preoperative treatment, and surgical management.

Results: In all, 10 patients (1.6%) had developed postoperative BPFs. Univariate logistic regression analysis showed that surgical procedure, medical history (arteriosclerosis obliterans [ASO]), and bronchial stump reinforcement were significant risk factors. Multivariate analysis showed that only surgical procedure (right lower lobectomy, p = 0.011, odds ratio = 17.4; right middle lower lobectomy, p = 0.003, odds ratio = 59.4; right pneumonectomy, p <0.001, odds ratio = 166.0) was a significant risk factor. Multivariate analysis confined to the surgical procedure of lobectomy showed that right lower lobectomy (p = 0.011, odds ratio = 36.5) and diabetes (HbA1c ≥8.0) (p = 0.022, odds ratio = 31.7) were significant risk factors.

Conclusion: When lobectomy or more radical surgery is performed for NSCLC, right lower lobectomy, middle lower lobectomy, and right pneumonectomy are significant risk factors for postoperative BPF. Thoracic surgeons should acquire the techniques of bronchoplasty and angioplasty to avoid such invasive procedures.

Keywords: bronchopleural fistula; lung cancer; risk factors.

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References

    1. Sonobe M, Nakagawa M, Ichinose M, et al. Analysis of risk factors in bronchopleural fistula after pulmonary resection for primary lung cancer. Eur J Cardiothorac Surg 2000; 18: 519- 23. - PubMed
    1. Kaplan DK, Whyte RI, Donnelly RJ. Pulmonary resection using automatic stapling devices. Eur J Cardiothorac Surg 1987; 1: 152- 7. - PubMed
    1. Lawrence GH, Ristroph R, Wood JA, et al. Methods for avoiding a dire surgical complication: bronchopleural fistula after pulmonary resection. Am J Surg 1982; 144: 136- 40. - PubMed
    1. Asamura H, Naruke T, Tsuchiya R, et al. Bronchopleural fistulas associated with lung cancer operations. Univariate and multivariate analysis of risk factors, management, and outcome. J Thorac Cardiovasc Surg 1992; 104: 1456- 64. - PubMed
    1. Dart CH, Scott SM, Takaro T. Six-year clinical experience using autotic stapling deces for lung resections. Ann Thorac Surg 1970; 9: 535- 50. - PubMed

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