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. 2020 Apr;35(2):158-168.
doi: 10.1007/s12291-018-0805-3. Epub 2019 Jan 2.

Polymorphisms of BIRC5 Gene is Associated with Chronic HBV Infection in Iranian Population

Bita Moudi  1   2 , Zahra Heidari  1   2 , Hamidreza Mahmoudzadeh-Sagheb  1   2
Affiliations

Polymorphisms of BIRC5 Gene is Associated with Chronic HBV Infection in Iranian Population

Bita Moudi et al. Indian J Clin Biochem. 2020 Apr.

Abstract

Survivin can affect the progression of infection and is considered as a marker of various malignancies. The aim of the study was to investigate the possible association of gene polymorphisms of survivin (-1547A/G, -644C/T, -625 C/G, -241C/T, -31G/C, -141G/C) and chronic hepatitis B infection in Iranian patients. The genotypes of survivin SNPs were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method using 100 chronic HBV infected patients (HBV), 40 spontaneously recovered HBV subjects and 100 healthy controls (C). Serum level of survivin was determined using ELISA method. The -1547G, -625C, -241T and -31C alleles were associated with increased susceptibility to chronic hepatitis B infection (P = 0.001, P < 0.001, P = 0.003 and P < 0.001 respectively). Chronic HBV patients with -625CC, -241TT and -31CC genotypes had higher levels of survvin. Survivin -1547A/G, -625 C/G, -241C/T and -31G/C gene polymorphisms may be associated with chronic HBV susceptibility in Iranian HBV patients.

Keywords: Chronic hepatitis B; Polymorphisms; Survivin.

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Conflict of interest statement

Conflict of interestThe authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Comparison of survivin levels between chronic hepatitis B (HBV) patients, spontaneously recovered (SR) subjects and control group (C). *P < 0.001, Compared to the C and SR groups
See this image and copyright information in PMC

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