Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2020 Jun 16;172(12):819-821.
doi: 10.7326/M20-1223. Epub 2020 Mar 30.

A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19

Collaborators, Affiliations
Editorial

A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19

Alfred H J Kim et al. Ann Intern Med. .

Erratum in

Abstract

Hydroxychloroquine, an essential treatment for many patients with rheumatologic conditions, has recently garnered widespread attention as a potential treatment for COVID-19 infection. The authors appraise the study generating this interest and highlight the potential consequences of rapid dissemination of overinterpreted data, particularly for people with conditions for which hydroxychloroquine has demonstrated benefits in preventing organ damage and life-threatening disease flares.

Keywords: Antimalarials; Biomarkers; COVID-19; Chloroquine; Intensive care units; Metastasis; Polymerase chain reaction; Post-exposure prophylaxis; Safety; Viral load.

PubMed Disclaimer

Figures

Figure.
Figure.
Global Google Trends search patterns for “hydroxychloroquine,” “chloroquine,” and “hydroxychloroquine shortage,” 16 to 22 March 2020. The spike on 17 March corresponded with the publication of Gautret and colleagues' report (4). The second spike on 20 March followed the U.S. presidential press conference in which hydroxychloroquine was described as a treatment of coronavirus disease 2019.

References

    1. Liu J, Cao R, Xu M, et al. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discov. 2020;6:16. [PMID: 32194981] doi:10.1038/s41421-020-0156-0. - PMC - PubMed
    1. Wang M, Cao R, Zhang L, et al. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro [Letter]. Cell Res. 2020;30:269-271. [PMID: 32020029] doi:10.1038/s41422-020-0282-0. - PMC - PubMed
    1. Yao X, Ye F, Zhang M, et al. In vitro antiviral activity and projection of optimized dosing design of hydroxychloroquine for the treatment of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Clin Infect Dis. 2020. [PMID: 32150618] doi:10.1093/cid/ciaa237. - PMC - PubMed
    1. Gautret P, Lagier JC, Parola P, et al. Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial. Int J Antimicrob Agents. 2020:105949. [PMID: 32205204] doi:10.1016/j.ijantimicag.2020.105949. - PMC - PubMed
    1. Dahly D, Gates S, Morris T. Statistical review of hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label nonrandomized clinical trial. Preprint. Posted online 23 March 2020. Zenodo. doi:10.5281/zenodo.3725560.

Publication types