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. 2020 Apr 23;382(17):1653-1659.
doi: 10.1056/NEJMsr2005760. Epub 2020 Mar 30.

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

Muthiah Vaduganathan  1 , Orly Vardeny  1 , Thomas Michel  1 , John J V McMurray  1 , Marc A Pfeffer  1 , Scott D Solomon  1
Affiliations

Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

Muthiah Vaduganathan et al. N Engl J Med. .
No abstract available

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Figures

Figure 1
Figure 1. Interaction between SARS-CoV-2 and the Renin–Angiotensin–Aldosterone System.
Shown is the initial entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into cells, primarily type II pneumocytes, after binding to its functional receptor, angiotensin-converting enzyme 2 (ACE2). After endocytosis of the viral complex, surface ACE2 is further down-regulated, resulting in unopposed angiotensin II accumulation. Local activation of the renin–angiotensin–aldosterone system may mediate lung injury responses to viral insults. ACE denotes angiotensin-converting enzyme, and ARB angiotensin-receptor blocker.
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References

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