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Review
. 2020 Mar 27;69(Suppl 1):S81-S92.
doi: 10.33549/physiolres.934406.

Drug-Induced Cough

J-S Shim  1 , W-J Song, A H Morice
Affiliations
Review

Drug-Induced Cough

J-S Shim et al. Physiol Res. .

Abstract

Since the recognition of angiotensin-converting enzyme inhibitors (ACEIs)-induced cough, drug has been considered as a potential cause of chronic cough. This review presents recent knowledge on drug-induced coughs in patients with chronic cough. The focus is placed on ACEIs, for which there are a multitude of studies documenting their associations with cough. Additional drugs are discussed for which there are reports of cough as a side effect of treatment, and the potential mechanisms of these effects are discussed.

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Conflict of interest statement

Conflict of Interest

There is no conflict of interest.

Figures

Fig. 1
Fig. 1
Schematic presentation of drug-induced cough reflex hypersensitivity
Fig. 2
Fig. 2
Effects of angiotensin converting enzyme inhibitors on blood pressure and cough. Angiotensin-converting enzyme (ACE) mediates the conversion of angiotensin I to angiotensin II, but also it is involved in the degradation of bradykinin and substance P; thus, the inhibition of ACE may lead to undesired respiratory tract sensitivity including cough.
See this image and copyright information in PMC

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