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Editorial
. 2020 Mar 27;25(7):1526.
doi: 10.3390/molecules25071526.

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides

Katherine Seley-Radtke  1
Affiliations
Editorial

Discovery, Design, Synthesis, and Application of Nucleoside/Nucleotides

Katherine Seley-Radtke. Molecules. .

Abstract

For decades, nucleosides and nucleotides have formed the cornerstone of antiviral, antiparasitic and anticancer therapeutics and have been used as tools in exploring nucleic acid structure and function [...].

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Conflict of interest statement

The author declares no conflicts of interest.

References

    1. Seley-Radtke K.L., Yates M.K. The evolution of nucleoside analogue antivirals: A review for chemists and non-chemists. Part 1: Early structural modifications to the nucleoside scaffold. Antivir. Res. 2018;154:66–86. doi: 10.1016/j.antiviral.2018.04.004. - DOI - PMC - PubMed
    1. Yates M.K., Seley-Radtke K.L. The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold. Antivir. Res. 2019;162:5–21. doi: 10.1016/j.antiviral.2018.11.016. - DOI - PMC - PubMed
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    1. Peters H.L., Jochmans D., de Wilde A.H., Posthuma C.C., Snijder E.J., Neyts J., Seley-Radtke K.L. Design, synthesis and evaluation of a series of acyclic fleximer nucleoside analogues with anti-coronavirus activity. Bioorg. Med. Chem. Lett. 2015;25:2923–2926. doi: 10.1016/j.bmcl.2015.05.039. - DOI - PMC - PubMed
    1. Yates M.K., Raje M.R., Chatterjee P., Spiropoulou C.F., Bavari S., Flint M., Soloveva V., Seley-Radtke K.L. Flex-nucleoside analogues—Novel therapeutics against filoviruses. Bioorg. Med. Chem. Lett. 2017;27:2800–2802. doi: 10.1016/j.bmcl.2017.04.069. - DOI - PMC - PubMed

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