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Review
. 2020 Apr;27(4):313-318.
doi: 10.1038/s41594-020-0400-1. Epub 2020 Mar 30.

Heterochromatin replication goes hand in hand with telomere protection

Aaron Mendez-Bermudez  1   2 , Marie-Josèphe Giraud-Panis  1 , Jing Ye  3 , Eric Gilson  4   5   6
Affiliations
Review

Heterochromatin replication goes hand in hand with telomere protection

Aaron Mendez-Bermudez et al. Nat Struct Mol Biol. 2020 Apr.

Abstract

Telomeres arose from the need to stabilize natural chromosome ends, resulting in terminal chromatin structures with specific protective functions. Their constituent proteins also execute general functions within heterochromatin, mediating late replication and facilitating fork progression. Emerging insights into the mechanisms governing heterochromatin replication suggest telomeres and heterochromatin act in concert during development and aging. They also suggest a common evolutionary origin for these two chromosome regions that arose during eukaryogenesis.

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References

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