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Review
. 2020 Apr;22(4):361-371.
doi: 10.1038/s41556-020-0487-y. Epub 2020 Mar 30.

Chromatin replication and epigenetic cell memory

Kathleen R Stewart-Morgan  1   2 , Nataliya Petryk  2   3 , Anja Groth  4   5
Affiliations
Review

Chromatin replication and epigenetic cell memory

Kathleen R Stewart-Morgan et al. Nat Cell Biol. 2020 Apr.

Abstract

Propagation of the chromatin landscape across cell divisions is central to epigenetic cell memory. Mechanistic analysis of the interplay between DNA replication, the cell cycle, and the epigenome has provided insights into replication-coupled chromatin assembly and post-replicative chromatin maintenance. These breakthroughs are critical for defining how proliferation impacts the epigenome during cell identity changes in development and disease. Here we review these findings in the broader context of epigenetic inheritance across mitotic cell division.

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