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Comment
. 2020 May;16(5):255-256.
doi: 10.1038/s41581-020-0270-0.

mGWAS: next generation genetic prediction in kidney disease

Daniel Montemayor  1 , Kumar Sharma  2
Affiliations
Comment

mGWAS: next generation genetic prediction in kidney disease

Daniel Montemayor et al. Nat Rev Nephrol. 2020 May.

Abstract

A recent metabolite genome-wide association study (mGWAS) investigated the relationship between genetic factors and the urine metabolome in kidney disease. The findings demonstrate that mGWAS hold promise for identifying novel genetic factors involved in adsorption, distribution, metabolism and excretion of metabolites and pharmaceuticals, as well as biomarkers for disease progression.

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Conflict of interest statement

Competing interests

The authors declare no competing interests.

Comment on

  • Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans.
    Schlosser P, Li Y, Sekula P, Raffler J, Grundner-Culemann F, Pietzner M, Cheng Y, Wuttke M, Steinbrenner I, Schultheiss UT, Kotsis F, Kacprowski T, Forer L, Hausknecht B, Ekici AB, Nauck M, Völker U; GCKD Investigators; Walz G, Oefner PJ, Kronenberg F, Mohney RP, Köttgen M, Suhre K, Eckardt KU, Kastenmüller G, Köttgen A. Schlosser P, et al. Nat Genet. 2020 Feb;52(2):167-176. doi: 10.1038/s41588-019-0567-8. Epub 2020 Jan 20. Nat Genet. 2020. PMID: 31959995 Free PMC article.

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