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. 2020 Oct;92(10):1721-1723.
doi: 10.1002/jmv.25804. Epub 2020 Apr 17.

CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19)

Pengfei Sun  1 , Xiaosheng Lu  2 , Chao Xu  1 , Yanjin Wang  3 , Wenjuan Sun  4 , Jianing Xi  5
Affiliations

CD-sACE2 inclusion compounds: An effective treatment for coronavirus disease 2019 (COVID-19)

Pengfei Sun et al. J Med Virol. 2020 Oct.

Abstract

Coronaviruses are common human viruses and include the severe acute respiratory syndrome coronavirus (SARS-CoV), the middle east respiratory syndrome coronavirus and the SARS-CoV-2. Coronaviruses mainly bind to transmembrane receptor proteins on the human cell membrane through spike proteins (S-proteins), thus releasing the RNA of the virus into the interior of the host cell to cause an infection. In this article, we discuss the mechanism and production of cyclodextrin-soluble angiotensin-converting enzyme 2 (CD-sACE2) inclusion compounds in the treatment of SARS-CoV-2 infections by blocking S-proteins. On the basis of the current research evidence, we believe that CD-sACE2 inclusion compounds have the potential to treat COVID-19. We hope that our article can provide a theoretical basis for later experiments.

Keywords: 2019-nCoV; ACE2; COVID-19; coronavirus; cyclodextrin.

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References

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