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. 2020 Oct;36(7):e3319.
doi: 10.1002/dmrr.3319. Epub 2020 Apr 7.

Diabetes is a risk factor for the progression and prognosis of COVID-19

Weina Guo  1 , Mingyue Li  1 , Yalan Dong  1 , Haifeng Zhou  1 , Zili Zhang  1 , Chunxia Tian  1 , Renjie Qin  1 , Haijun Wang  2 , Yin Shen  2 , Keye Du  2 , Lei Zhao  3 , Heng Fan  1 , Shanshan Luo  4 , Desheng Hu  1   4
Affiliations

Diabetes is a risk factor for the progression and prognosis of COVID-19

Weina Guo et al. Diabetes Metab Res Rev. 2020 Oct.

Abstract

Backgound: To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).

Methods: A total of 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed.

Results: We found that COVID-19 patients without other comorbidities but with diabetes (n = 24) were at higher risk of severe pneumonia, release of tissue injury-related enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarkers such as IL-6, C-reactive protein, serum ferritin and coagulation index, D-dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19.

Conclusions: Our data support the notion that diabetes should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to patients with diabetes, in case of rapid deterioration.

Keywords: COVID-19; diabetes; prognosis.

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Conflict of interest statement

The authors declare that they do not have any conflict of interest regarding this publication.

Figures

FIGURE 1
FIGURE 1
CT results of the patients with diabetes and patients without diabetes. A. The representative CT images of the patients with diabetes and patients without diabetes. B, The CT score of the patients with diabetes and patients without diabetes. P < .05 was considered statistically significant. CT, computed tomography
FIGURE 2
FIGURE 2
Biochemical examination results of the patients with diabetes and patients without diabetes. P < .05 was considered statistically significant
FIGURE 3
FIGURE 3
Other laboratory tests of the patients with diabetes and patients without diabetes. A, Blood test results of the patients with diabetes and patients without diabetes. B, Inflammation‐related laboratory results of the patients with diabetes and patients without diabetes. C, Coagulation‐related laboratory results of the patients with diabetes and patient without diabetes. P < .05 was considered statistically significant
See this image and copyright information in PMC

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References

    1. Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):507‐513. - PMC - PubMed
    1. Kuba K, Imai Y, Rao S, et al. A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus‐induced lung injury. Nat Med. 2005;11(8):875‐879. - PMC - PubMed
    1. Wrapp D, Wang N, Corbett KS, et al. Cryo‐EM structure of the 2019‐nCoV spike in the prefusion conformation. Science. 2020;367:1260‐1263. - PMC - PubMed
    1. Patel VB, Zhong JC, Grant MB, Oudit GY. Role of the ACE2/angiotensin 1‐7 Axis of the renin‐angiotensin system in heart failure. Circ Res. 2016;118(8):1313‐1326. - PMC - PubMed
    1. Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin‐converting enzyme. Cloning and functional expression as a captopril‐insensitive carboxypeptidase. J Biol Chem. 2000;275(43):33238‐33243. - PubMed