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Review
. 2020 Nov 3;50(SI-2):1691-1696.
doi: 10.3906/sag-2003-138.

Data-Driven identification of chemopreventive agents for breast cancer

Deniz Can Güven  1 , Cemal Orhan  2 , Kazim Şahin  2 , Fatih M. Uçkun  3   4
Affiliations
Review

Data-Driven identification of chemopreventive agents for breast cancer

Deniz Can Güven et al. Turk J Med Sci. .

Abstract

Preclinical animal models of breast cancer provide the opportunity to identify chemopreventive drugs with single-agent activity as well as effective multi-modality regimens for primary as well as secondary prevention in high-risk persons. Our group has used the 7,12-dimethylbenz(a)anthracene (DMBA) mouse model of carcinogen-induced breast cancer to explore the clinical potential of two tyrosine kinase inhibitors and a nucleoside analog as chemopreventive agents. All three agents exhibited promising preclinical activity both as monotherapy and as components of combination therapy with the standard chemotherapy drug paclitaxel. The tumors developing despite chemoprevention were not only small and grew slowly, but they also displayed a uniquely more pro-apoptotic protein expression profile. Hence, our experimental chemopreventive drugs were capable of preventing the development of aggressive mammary gland tumors with an apoptosis-resistant protein expression profile.

Keywords: Breast cancer; LFM-A13; WHI-P131; stampidine.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Effects of paclitaxel on the proportion of tumor-free survival (a) and macroscopic appearance and histopathological features (b; H&E X200) of DMBA-induced tumors in the mammary glands of mice.
Figure 2
Figure 2
Effects of chemoprevention with paclitaxel, LFM-A13, WHI-P131 and stampidine on proportion tumorfree survive in DMBA-challenged mice.
Figure 3
Figure 3
Effects of chemoprevention with paclitaxel, LFM-A13, WHI-P131 and stampidine on the tumor size in DMBA-challenged mice.
Figure 4
Figure 4
Effects of chemoprevention with paclitaxel, LFM-A13, WHI-P131 and stampidine on total tumor load in DMBA-challenged mice.
See this image and copyright information in PMC

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