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. 2020 Jan-Dec;27(1):1073274820915514.
doi: 10.1177/1073274820915514.

Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location

Wan-Joon Kim  1 , Tae-Wan Lim  2 , Pyoung-Jae Park  2 , Sae-Byeol Choi  1 , Wan-Bae Kim  1
Affiliations

Clinicopathological Differences in T2 Gallbladder Cancer According to Tumor Location

Wan-Joon Kim et al. Cancer Control. 2020 Jan-Dec.

Abstract

We aimed to identify clinicopathological differences and factors affecting survival outcomes of stage T2a and T2b gallbladder cancer (GBC) and validate the oncological benefits of regional lymphadenectomy and hepatic resection in these patients. This single-center study enrolled patients who were diagnosed with pathologically confirmed T2 GBC and underwent curative resection between January 1995 and December 2017. Eighty-two patients with T2a and 50 with T2b GBCs were identified, and clinical information was retrospectively collected from medical records and analyzed. Five-year overall survival rates were 96.8% and 80.7% in T2a and T2b groups, respectively (P = .007). Three- and 5-year survival rates among all patients with T2 GBC without and with lymph node metastasis were 97.2% and 94.4% and 81.3% and 81.3%, respectively (P = .029). There was no difference in survival rates between the 2 groups according to whether hepatic resection was performed (P = .320). However, in the T2b group, those who underwent hepatic resection demonstrated a better survival rate than those who did not (P = .029). The T2b group had more multiple recurrence patterns than the T2a group, and the lymph nodes were the most common site in both groups. Multivariate analysis revealed that lymph node metastasis, vascular invasion, and tumor location were significant independent prognostic factors. Hepatic resection was not always necessary in patients with peritoneal-side GBC. Considering clinicopathological features and recurrence patterns, a systematic treatment plan, including radical resection and adjuvant treatment, should be established for hepatic-side GBC.

Keywords: gallbladder carcinoma; hepatic resection; lymphadenectomy; survival rate; tumor location.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Overall survival rate in T2 GBC according to tumor location. Patients with GBC with T2a do achieve better overall survival than T2b (P = .007). GBC indicates gallbladder cancer.
Figure 2.
Figure 2.
Overall survival rate in T2 GBC according to regional lymphadenectomy in T2a(A) and T2b(B) and according to hepatic resection in T2a(C) and T2b(D). GBC indicates gallbladder cancer.
See this image and copyright information in PMC

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